Results 91 to 100 of about 74,986 (277)

Bilateral pheochromocytoma with ganglioneuroma component associated with multiple neuroendocrine neoplasia type 2A: a case report

Journal of Medical Case Reports, 2017
Background Composite pheochromocytoma/paragangliomas are very rare tumors composed of ordinary pheochromocytoma paragangliomas associated with neurogenic tumors. Several hereditary susceptibility disorders are known to be associated with pheochromocytoma/
Boubacar Efared, Gabrielle Atsame-Ebang, Soufiane Tahirou, Khalid Mazaz, Nawal Hammas, Hinde El Fatemi, Laila Chbani   +6 more
doaj   +1 more source

Absence of an embryonic stem cell DNA methylation signature in human cancer. [PDF]

, 2019
BackgroundDifferentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture
Christensen, Brock C, Kelsey, Karl T, Koestler, Devin C, Salas, Lucas A, Wiencke, John K, Zhang, Ze   +5 more
core  

Transcriptional Profiles for Glutamate Transporters Reveal Differences Between Organophosphates but Similarities with Unrelated Neurotoxicants [PDF]

, 2010
The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress.
Lobner, Doug, Seidler, Frederic J., Slotkin, Theodore A.   +2 more
core   +2 more sources

Bilateral nontraumatic subcapsular renal haematoma (Wunderlich syndrome) in a Thoroughbred broodmare

Equine Veterinary Education, EarlyView.
Summary This case report describes a Thoroughbred broodmare referred for colic and pyrexia. The mare had a history of repeated urinary tract infections, placentitis, abortion and endotoxaemia. A diagnosis of bilateral subcapsular renal haematoma was made by ultrasonography and standing laparoscopy and confirmed on post‐mortem.
M. Hannan, D. Verwilghen, F. Gibbons, C. Burden, R. Liechti, O. Forde, N. Meyer, V. Roati, B. Remaj, G. van Galen   +9 more
wiley   +1 more source

The Transcriptional Corepressor NAB2 Inhibits NGF-induced Differentiation of PC12 Cells [PDF]

, 1998
The PC12 pheochromocytoma cell line responds to NGF by undergoing growth arrest and proceeding to differentiate toward a neuronal phenotype. Among the early genetic events triggered by NGF in PC12 cells are the rapid activation of the zinc finger ...
Davidson, Norman, Ehrengruber, Markus U., Milbrandt, Jeffrey, Qu, Zhican, Svaren, John, Wolfraim, Lawrence A.   +5 more
core   +2 more sources

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Introduction of d-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity. [PDF]

, 2016
The amyloid beta peptide 42 (Aβ42) is an aggregation-prone peptide that plays a pivotal role in Alzheimer's disease. We report that a subtle perturbation to the peptide through a single chirality change at glutamate 22 leads to a pronounced delay in the ...
Dutta, Subrata, Foley, Alejandro R, Raskatov, Jevgenij A, Warner, Christopher JA   +3 more
core   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Pheochromocytoma [PDF]

Cancer, 1972
S, Warren, R N, Chute
openaire   +4 more sources

‘Case of the Month’ from the University of Verona, Italy—navigating the medical and surgical challenges of urinary bladder paraganglioma: insights from a clinical case

BJU International, Volume 135, Issue 5, Page 743-747, May 2025.
Lorenzo Pierangelo Treccani, Francesco Artoni, Claudio Brancelli, Alessandro Veccia, Mirko D'Onofrio, Isabella Pichiri, Matteo Brunelli, Riccardo Giuseppe Bertolo, Alessandro Antonelli   +8 more
wiley   +1 more source