Results 71 to 80 of about 20,103 (275)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Revisión biogeográfica de los marsupiales del Parque Nacional del Manú, Perú

open access: yesEspacio y Desarrollo, 1991
Se revisó los datos biogeográficos de las 9 especies de marsupiales presentes en el Parque Nacional del Manú, Estación Biológica de Cocha Cashu y Puesto de Pakitza, según fuentes escritas, datos de colecta de los museos de Historia Natural de la ...
Bethzabé Guevara Gálvez
doaj  

Experimental and numerical investigation into the behavior of shape memory alloys

open access: yesJournal of the Mechanical Behavior of Materials, 2012
Research and development of smart alignment systems is currently being undertaken at the Smart Devices and MEMS Laboratory at the Cape Peninsula University of Technology.
Philander Oscar   +2 more
doaj   +1 more source

Morphometric analysis of the patella and patellar ligament of South Africans of European ancestry

open access: yesSouth African Journal of Science, 2013
Morphometric analyses of the patella and patellar ligament have been reported to be important in human identification, in knee implant design and in certain surgical procedures of the knee.
Oladiran I. Olateju   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Humoral Immune Response Kinetics in Philander opossum and Didelphis marsupialis Infected and Immunized by Trypanosoma cruzi Employing an Immunofluorescence Antibody Test

open access: yesMemorias do Instituto Oswaldo Cruz, 1999
Philander opossum and Didelphis marsupialis considered the most ancient mammals and an evolutionary success, maintain parasitism by Trypanosoma cruzi without developing any apparent disease or important tissue lesion.
Ana Paula Legey   +4 more
doaj   +1 more source

Cooperation and Stability through Periodic Impulse [PDF]

open access: yes, 2010
Basic games, where each individual chooses between two strategies, illustrate several issues that immediately emerge from the standard approach that applies strategic reasoning, based on rational decisions, to predict population behavior where no ...
Cressman, Ross, Tao, Yi, Zhang, Bo-Yu
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Playing by the rules: Government regulation and consumer trust in the online poker industry

open access: yesComputers in Human Behavior Reports
This study examines how government regulation can affect consumer trust and the perceived value of digital services. Data from interviews, a focus group, and a discrete choice experiment conducted by online poker players find that regulation ...
Kahlil S. Philander, Bradley S. Wimmer
doaj   +1 more source

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