Results 131 to 140 of about 15,929,032 (230)

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo   +7 more
wiley   +1 more source

The Development of A mathematical Model to Predict Runoff From A micro-catchment under High Water Application Rates [PDF]

open access: yes, 1988
Current trends in sprinkler irrigation to improve application uniformity and reduce energy requirements haste led to problems of water application and potential surface runoff, which in turn have highlighted the importance of the soil and cultivation
Abo-Ghobar, Hussein Mohammed Ali
core  

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell   +11 more
wiley   +1 more source

Leg glucose uptake and substrate utilisation during time trial exercise: Effects of acute hypobaric hypoxia and biological sex

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐two highly trained individuals (12 males and 10 females) completed a 30 min self‐paced maximal cycling time trial in normoxia (∼400 m) and acute hypobaric hypoxia (∼2800 m) in a counterbalanced cross‐over design. Pulmonary gas exchange, femoral artery and vein catheterisation with leg blood flow measurements, and muscle ...
Anders Aagaard Hansen   +11 more
wiley   +1 more source

Optimizing IMPULSED Acquisition Protocols for Clinical 3T Scanners Through Bayesian Experimental Design

open access: yesMagnetic Resonance in Medicine, Volume 97, Issue 1, Page 100-113, January 2027.
ABSTRACT Purpose To optimize diffusion MRI acquisition protocols for Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion (IMPULSED) model at clinical 3T scanner using Bayesian experimental design, enabling accurate cellular‐scale parameter estimation under realistic scan time and scanner hardware constraints.
Yan Dai   +6 more
wiley   +1 more source

HierAnom‐Path: Zero‐Shot Rare Cancer Detection in Histopathology via Hierarchical Foundation Model Adaptation

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Rare cancers collectively represent 20%–25% of all malignancies yet yield fewer than 50 annotated whole‐slide images (WSIs) per subtype in publicly available archives, rendering supervised deep learning inapplicable. We present HierAnom‐Path, to the best of our knowledge, the first framework for zero‐shot rare cancer anomaly detection in ...
Noora Saleem Jumaah   +5 more
wiley   +1 more source

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

open access: yesGlia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom   +11 more
wiley   +1 more source

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

open access: yesJournal of Cutaneous Pathology, Volume 53, Issue 12, Page 1131-1141, December 2026.
ABSTRACT Background Anti‐PD‐1 response has been associated with higher PD‐1 ligand (PD‐L1) expression levels in different cancer types. Cemiplimab, an anti‐PD‐1 antibody, has been shown to induce a response rate of 31% and 22% in patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC respectively, who have progressed or are ...
Isabella Dommann   +9 more
wiley   +1 more source

A Practical Integrated 1D–2D Hydrodynamic Modelling Approach for Evaluating the Surface Water Management Impact of Distributed Retrofit Sustainable Drainage Systems at the Concept Stage

open access: yesJournal of Flood Risk Management, Volume 19, Issue 4, December 2026.
ABSTRACT There is increasing interest among decision makers in retrofitting large numbers of sustainable drainage systems (SuDS) across urban areas to help deal with the growing issue of pluvial flooding. For the practitioner an important early stage in the development of a retrofit SuDS scenario is the optioneering process, when it is desirable to ...
Phil Williams   +6 more
wiley   +1 more source

Cyanobacterium Brasilonema sp. LPS Induces Neutrophil Infiltration and Lung Inflammation in a TLR4-Dependent Manner and Exacerbates Th2-Dependent Lung Inflammation. [PDF]

open access: yesImmun Inflamm Dis
Swartzendruber J   +9 more
europepmc   +1 more source

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