Results 51 to 60 of about 15,929,032 (230)

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Effects of Subsoiling with Different Wing Mounting Heights on Soil Water Infiltration Using HYDRUS-2D Simulations

Agronomy, 2023
Subsoiling is an essential practice in conservation tillage technology. The amount of disturbed soil at various depths resulting from subsoilers with different parameters has an important effect on soil properties (e.g., bulk density and water ...
Xuezhen Wang, Lingxin Geng, Hanmi Zhou, Yuxiang Huang, Jiangtao Ji   +4 more
doaj   +1 more source

LLM‐Based Multimodal Robotic Endoscope Control Framework for Enhancing Human–Robot Interaction in Minimally Invasive Surgery

Advanced Intelligent Systems, EarlyView.
An large language model‐powered multimodal framework is developed for robotic endoscope control. It integrates speech recognition and real‐time instrument tracking, achieving 89.47% command accuracy with ~1s latency for natural human–robot interaction in minimally invasive surgery.
Yisen Huang, Wing Yin Ng, Qi Dou, Xixin Wu, Shannon Melissa Chan, Yunhui Liu, Philip Wai Yan Chiu, Zheng Li   +7 more
wiley   +1 more source

Evaluation of infiltration models for mineral soils with different land uses in the tropics

Journal of Water and Land Development, 2018
The aims of this study were to evaluate five infiltration models for mineral soils in the tropics with different land use types, such as settlements, plantations, rice fields, and forests.
Suryoputro Nugroho, Suhardjono, Soetopo Widandi, Suhartanto Ery S., Limantara Lily M.   +4 more
doaj   +1 more source

Arthrogryposis Multiplex Congenita in Pediatric Age: Correlation Between MUScular MRI and Functional Evaluation (AMUSE), Toward a Biomechanical Model

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) is a group of diseases with joint limitations at two or more distinct joint levels at birth. Joint limitations are not progressive, but the functional consequences have a lifelong impact on patients. The management of these conditions is therefore demanding, necessarily multidisciplinary, and is a long ...
Alicia‐Marine Milot, Mariya Raykova, Claire Huzar, Véronique Thellier, Nicolas Hergibo, Marjolaine Gauthier, Gipsy Billy‐Lopez, Chantal Durand, Frédérique Nugues, Véronique Bourg, Klaus Dieterich   +10 more
wiley   +1 more source

Evaluation and comparison of infiltration models under different soil textures in the Mamprusi west district of North East Region, Ghana

Environmental Systems Research
Assessment of soil water infiltration through reliable estimation of the infiltration rate is key to informed decision-making for sustainable ecosystem management. This study was conducted to evaluate the performances of the Kostiakov, Modified Kostiakov,
T. Atta-Darkwa, A. Asare, K. A. Asosega, Y. Seidu, E. T. Atakora, G. A. Akolgo, E. A. Awafo, D. N. D. Quaye, E K Nyantakyi, Ebenezer K. Siabi, J. O.A Akimsah   +10 more
doaj   +1 more source

Water erosion and soil water infiltration in different stages of corn development and tillage systems

Revista Brasileira de Engenharia Agrícola e Ambiental, 2015
This study evaluated soil and water losses, soil water infiltration and infiltration rate models in soil tillage systems and corn (Zea mays, L.) development stages under simulated rainfall.
Daniel F. de Carvalho, Eliete N. Eduardo, Wilk S. de Almeida, Lucas A. F. Santos, Teodorico Alves Sobrinho   +4 more
doaj   +1 more source

Selective Cell‐Repellent 3D Scaffold Platform for Proton Radiobiology

Advanced NanoBiomed Research, EarlyView.
A selective cell‐repellent 3D scaffold platform is developed to minimize unwanted 2D cell populations surrounding engineered cell microenvironments. The approach is based on the combination of Lipidure coatings with two‐photon polymerized scaffolds and enables specific characterization of glioblastoma cells’ response to proton irradiation.
Novinda S. Pertiwi, Qais Akolawala, Rob van den Akker, Anggraeini Puspitasari‐Kokko, Henri H. Versteeg, Araci M. R. Rondon, Angelo Accardo   +6 more
wiley   +1 more source