Results 21 to 30 of about 602,448 (299)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Ventas jurisdiccionales abulenses en tiempos de Felipe III y Felipe IV

open access: yesStudia Historica: Historia Moderna, 2009
RESUMEN: Este trabajo tiene por objeto dar a conocer las enajenaciones jurisdiccionales, —excluidas las ventas de oficios— llevadas a cabo por Felipe III y Felipe IV en la provincia de Ávila.
Francisco Javier LORENZO PINAR   +1 more
doaj   +2 more sources

Une reine entre ombres et lumières ou le pouvoir au féminin : le cas d’Isabelle Bourbon, reine d’Espagne, première femme de Philippe IV (1603-1644)

open access: yesGenre & Histoire, 2009
The role of French queens and their relation to power were strictly regulated, but their political influence is difficult to assess given the shadows within which they worked. In 1615, Isabelle of Bourbon, born Princess of France, married Philip of Spain
Frédérique Sicard
doaj   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt   +8 more
wiley   +1 more source

The Transatlantic Mediation of Historical Knowledge across the Iberian Empire (c1580-c1640)

open access: yesE-Spania, 2014
During the time of the Political Turn in the historiography of the Iberian Empire (1580-1640), the parallel careers of the royal historiographer Antonio de Herrera and the would-be historian Francisco Caro de Torres are indicative of the developing ...
Fabien Montcher
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett   +8 more
wiley   +1 more source

¿Judith or Esther? The Rembrandt of the Prado Museum

open access: yesAnales de Historia del Arte, 2014
The painting by Rembrandt in the Museo del Prado, which belonged to Philip IV´s secretary, don Jerónimo de la Torre, has been the object of three identifications: Artemisia, Sophonisba or Judith.
Juan María Cruz Yábar
doaj   +1 more source

El camino a Carlos II. Haro, Felipe IV y la restauración del gobierno personal en España = The Road to Carlos II. Haro, Felipe IV and the Restoration of Personal Government in Spain

open access: yesEspacio, Tiempo y Forma. Serie IV, Historia Moderna, 2020
La relación entre España y Francia a partir de 1661 revistió un interés particular a causa de la confluencia de dos fenómenos: el fin de la hegemonía hispánica y la extinción del valimiento en ambas coronas.
Rafael Valladares
doaj   +1 more source

Une lecture politique des Col·loquis de la insigne ciutat de Tortosa (1557) de Cristòfol Despuig

open access: yesE-Spania, 2021
This paper offers a political reading of the Col·loquis de la insigne ciutat de Tortosa (1557), by the Catalan author Cristòfol Despuig. It is dedicated to a study of some of the political and historical themes, especially the Civil War between John II ...
Mathias Ledroit
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown   +6 more
wiley   +1 more source

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