Results 61 to 70 of about 91,649 (245)

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

Deformable Eutectic Alloy With Near‐Theoretical Yield Strength via Hierarchical Nanoscale Multiphases and Sessile Defects

Advanced Science, EarlyView.
A CoCrFeNiTa0.4 eutectic high‐entropy alloy achieves a near‐theoretical yield strength of 2.6 GPa with 13.6% plasticity. This breakthrough stems from a hierarchical nanostructure (FCC‐Laves lamellae with L12/D022 precipitates), which alleviates the inter‐phase modulus/hardness mismatch through synergistic strengthening and toughening, guiding the ...
Yusha Luo, Qianqian Wang, Bo Sun, Ruixin Sheng, Zhijun Guo, Gaopeng Zou, Zhe Jia, Yang Tong, Gang Sha, Peter K. Liaw, Baolong Shen   +10 more
wiley   +1 more source

What methods do reviews of normative ethics literature use for search, selection, analysis, and synthesis? In-depth results from a systematic review of reviews

Systematic Reviews, 2017
Background (Semi-)systematic approaches to finding, analysing, and synthesising ethics literature on medical topics are still in their infancy. However, our recent systematic review showed that the rate of publication of such (semi-)systematic reviews ...
Marcel Mertz, Daniel Strech, Hannes Kahrass   +2 more
doaj   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

The Plastic Hospital: Catherine Malabou’s Architectural Therapeutics

Essays in French Literature and Culture, 2021
This article stages encounters between the contemporary French philosopher Catherine Malabou and the French Medical Humanities. Whilst Malabou’s philosophy of the body and brain focuses largely on sites of irreversible destruction and (neuro)pathology,
Benjamin Dalton
doaj  

Renewing Medicine’s basic concepts: on ambiguity

Philosophy, Ethics, and Humanities in Medicine, 2018
Background Edmund Pellegrino lamented that the cultural climate of the industrialized West had called the fundamental means and ends of medicine into question, leading him to propose a renewed reflection on medicine’s basic concepts, including health ...
Joel Michael Reynolds
doaj   +1 more source

Gutmann Donor Theory‐Guided Design of Mononuclear Ionic Cluster for Exceptional N‐Type Thermoelectric Ionogel

Advanced Science, EarlyView.
Super‐stretchable and self‐healing polyacrylate ternary ionogel elastomers are used for flexible i‐TE devices. Based on Gutmann donor theory of doped anion, the work proposes a three‐parameter tuning strategy of flexible polymer‐doped anion‐synergistic cation to achieve the systematic design of ionic thermoelectric materials. Abstract Quasi‐solid‐state,
Bin Chen, Mingxuan Tian, Hongji Wang, Yun Jin, Heng Tang, Xingrui Chen, Shengxue Yu, Changyuan Yan, Wenwei Lei, Taihong Wang   +9 more
wiley   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Application progress on empowerment philosophy in nursing care of patients with stroke

Huli yanjiu, 2016
With the development of human centered medical care model,empowerment philosophy has received extensive attention as a new and effective nursing intervention model.It reviwed the connotation and theoretical framework of empowerment philosophy as well ...
赵蒙, 牟善芳
doaj