Results 21 to 30 of about 4,602,009 (394)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Philosophy Kitchen, 2021 Sebbene la questione ecologica sia centrale nel dibattito filosofico e scientifico da oltre cinquant’anni – come «lo studio delle interrelazioni che intercorrono fra gli organismi e l’ambiente chi li ospita […] su tre livelli di gerarchia biologica ...
Philosophy Kitchen
doaj
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT This article explores how artificial intelligence (AI) is reshaping scholarly research and writing for faculty in higher education. As AI becomes increasingly integrated into academic workflows, it offers opportunities to enhance efficiency, exchange ideas, and foster creativity, while also raising critical questions about authorship ...
Adam L. McClain, Scott Barton
wiley +1 more source
Advanced Engineering Materials, EarlyView.This article presents a solver‐agnostic domain‐specific language (DSL) for computational structural mechanics that strengthens interoperability in virtual product development. Using a hierarchical data model, the DSL enables seamless exchange between diverse simulation tools and numerical methods.
Martin Rädel +3 more
wiley +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
A Few Reflexions on God, Philosophy, Theology, and Faith
Nova Prisutnost, 2020 In trying to understand God and faith in a proper way, philosophy and theology could be very complementary. I would like to review and examine a few modern challenges and relationships between philosophy, theology and faith, seen also from important ...
Davor Pećnjak
doaj +1 more source