Results 71 to 80 of about 2,769 (189)

Supercationic Poly(Hexamethylene Biguanide)‐Derived Carbon Dots for Combating Multidrug‐Resistant Bacterial Keratitis

Small Structures, Volume 7, Issue 3, March 2026.
This research introduces poly(hexamethylene biguanide)‐derived carbon dots (P‐CDs) as a novel antibacterial agent for combating multidrug‐resistant bacterial keratitis. P‐CDs exhibit potent activity against resistant pathogens, including MRSA and MRPA. In vivo results confirm their superior therapeutic efficacy over standard antibiotics, alongside the ...
Wenjie Fan, Tianji Feng, Hongxian Pan, Yin Zhang, Zhebin Chen, Qiao Jin, Haijie Han, Jian Ji, Ke Yao   +8 more
wiley   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
Good L, Chindera K, Sharma A, Kamaruzzamabn N, Stach J, Mahalo M, Horsley H, Kloc-Muniak K, McFarlane A, Bentin T, Kumar S   +10 more
core   +4 more sources

Implementing Wound Hygiene in the Italian Healthcare Context: Expert Recommendations for the Management of Venous Leg Ulcers

International Wound Journal, Volume 23, Issue 3, March 2026.
ABSTRACT The ‘Wound Hygiene Italia’ project was designed to provide expert‐driven recommendations for the assessment, management and monitoring of venous leg ulcers, tailored to diverse settings of care (hospital, ambulatory and home care). The recommendations, developed by a multidisciplinary panel, emphasise the implementation of the Wound Hygiene ...
Alessandro Scalise, Franco Bassetto, Diego Ceci, Guido Ciprandi, Deborah Cesura Granara, Barbara De Angelis, Ciro Falasconi, Domitilla Foghetti, Francesco Giacinto, Alessandro Greco, Filippo Magnoni, Marco Marchelli, Giuseppe Nebbioso, Battistino Paggi, Giovanni Papa, Francesco Petrella, Salvatore Piazza, Marco Romanelli, Elia Ricci, Sara Sandroni   +19 more
wiley   +1 more source

Mechanism(s) of action of PHMB on L. major promastigotes.

, 2015
PHMB disrupted membrane integrity and condensed DNA in L. major promastigotes. Representative FACS histogram (a) propidium iodide (PI) and (b) YO-PRO-1dye staining of promastigotes after treatment with 2 μM PHMB for indicated time points, showing time ...
Heidrun Moll (317342), Maria Cecilia Amstalden (802997), Liam Good (53703), Bianca Röger (634368), Nina Hecht (803001), Tobias A. Oelschlaeger (281562), Rebuma Firdessa (108932), Tessa Lühmann (803002), Lorenz Meinel (3509), Kantaraja Chindera (802998), Martina Schultheis (803000), Nor Fadhilah Kamaruzzaman (802999)   +11 more
core   +1 more source

Antimicrobial Efficacy of a Taurolidine‐Based Antimicrobial Compound on Contaminated Surfaces Simulated in a Standardized 4‐Field Test

Advanced Healthcare Materials, Volume 15, Issue 7, 16 February 2026.
As implantable medical devices become indispensable to modern medicine, a silent threat grows alongside them: device‐associated infections. Despite decades of antibiotic innovation, infection rates keep climbing, costing lives and billions in healthcare expenses.
Benito Baldauf, Hendrik Bonnemeier, Ernest W. Lau, Jana Hummel, Reinhard Vonthein, Ojan Assadian   +5 more
wiley   +1 more source

Comparison of antimicrobial efficacy and therapeutic index properties for common wound cleansing solutions, focusing on solutions containing PHMB

GMS Hygiene and Infection Control
Background: Surgical site infections (SSIs) have been shown to increase patient morbidity and mortality, impact on quality of life and place a significant economic burden on healthcare systems worldwide.
Watson, Fergus, Chen, Rui, Saint Bezard, Jeanne, Percival, Steven   +3 more
doaj   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Genetic diversity of Acanthamoeba and clinical outcome predictors in Danish patients with Acanthamoeba keratitis

Acta Ophthalmologica, Volume 104, Issue 1, Page 44-51, February 2026.
Abstract Purpose Acanthamoeba keratitis (AK) is a severe corneal infection with potential detrimental effects on visual outcome and quality of life, primarily affecting young contact lens wearers. We report Acanthamoeba genotypes, subtypes and clinical outcome from Danish patients with AK. Methods Thirty‐nine PCR‐positive AK cases diagnosed and treated
Sandra M. Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Anders Ivarsen   +5 more
wiley   +1 more source

Evaluation of the antimicrobial effect of polyhexamethylenebiguanide (PHMB) compared with chlorhexidinedigluconate (CHX) on a saliva microcosm biofilm: in vitro study

, 2021
A biguanida de polihexametileno (PHMB) é quimicamente semelhante ao digluconato de clorexidina (CHX), ambas biguanidas, porém cadeias terminais distintas, o que proporciona diferença na atividade terapêutica e perfil toxicológico.
Carvalho, Caroline Gomes
core   +1 more source

Cytotoxicity and antiseptic effects on PHMB-coated Ti

, 2017
published_or_final_version ; Dental Materials Science ; Master ; Master of Science in Dental Materials ...
openaire   +1 more source