Results 131 to 140 of about 161,196 (302)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

The Changes of P-fractions and Solubility of Phosphate Rock in Ultisol Treated by Organic Matter and Phosphate Rock

Journal of Tropical Soils, 2012
Phosphorus (P) is one of the essential elements for plant, however, its availability is mostly very low in acid soils. It is well documented that application of phosphate rock and organic matter are able to change the level of availability of P-form in ...
Heru Bagus Pulunggono, Budi Nugroho, Sri Djuniwati   +2 more
doaj  

First season maize performance in a long-term farming systems comparison trial at KARI-Thika, Kenya [PDF]

, 2009
Kenya’s smallholder farmers contribute 65% to total agricultural output in a predominantly mixed farming system where application of inorganic fertilizers and pesticides is minimal.
Muriuki, Anne, Musyoka, Martha, Mwangi, K, Schulthess, F, Zundel, Christine   +4 more
core  

Faster and Durable: A Cell‐to‐System Validation of a Low‐Degradation Fast‐Charge Protocol for Li‐Ion Batteries

Advanced Science, EarlyView.
A physics‐based framework resolving graphite phase‐separation dynamics establishes a predictive, degradation‐aware fast‐charging methodology for commercial Li‐ion batteries. The resulting model‐informed protocol achieves 20%–80% state‐of‐charge in 14 min while matching the long‐term degradation of a commercial 25‐minute EV strategy.
Marco Lagnoni, Francesco Giuseppe Quilici, Davide Cademartori, Claudio Scarpelli, Uways Nurulain Mithoowani, Federica Barontini, Alessandro Ruvio, Monica Puccini, Giovanni Lutzemberger, Maria Paola Carpanese, Antonio Bertei   +10 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Respon Tanaman Jagung Terhadap Pemupukan Fosfor Pada Typic Dystrudepts [PDF]

, 2009
On the acid soil, phosphorus nutrients become critical for agricultural crops growth. At the present, price of fertilizers significantly increase and fertilizers are not available. These conditions can affect on soil productivity and crop production. The
Kasno, A. (Antonius)
core  

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Interaction entre le fumier enrichi, le calcaire et les différentes sources de phosphore issues de la roche phosphatée de Matongo sur un ferralsol de la région du Bututsi (Burundi) [PDF]

Tropicultura, 1993
Interaction between enriched farmyard manure with fertilizers, lime and different phosphorus sources obtained from the phosphatic rock from Matongo on a ferralitic soil from the region of Bututsi (Burundi). This study on maize growing in pots shows that (
Rwigema, JB., Van den Berghe, CH., Mujawayezu, AM., Sota, P.   +3 more
doaj  

Efficiency, economics, and environmental implications of phosphorus resource use and the fertilizer industry in China [PDF]

Phosphorus (P) is an essential nutrient for crop production and is often in short supply. The necessary P fertilizers are derived from deposits in the lithosphere, which are limited in size and nonrenewable.
Fan, M.S., Ji, Y.X., Ma, W.Q., Oenema, O., Zhang, F.S., Zhang, W.F.   +5 more
core   +3 more sources