Results 161 to 170 of about 463,152 (355)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Mineralogical analysis in two caves from the Perşani Mountains

Travaux de l'Institut de Speologie Emile Racovitza, 2007
After diffractometric X-ray analyses through the powder method, made on sampling tests from two caves in the Perşani Mountains karst, mineral associations made up of calcite, magnesium calcite, aragonite, dolomite, brushite, hydroxylapatite, carbonate ...
GABRIEL DIACONU, DELIA-GEORGETA DUMITRAŞ, ŞTEFAN MARINCEA   +2 more
doaj  

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Dexamethasone and Dexamethasone Phosphate: Effect on DMPC Membrane Models [PDF]

, 2023
Candelaria I. Cámara, Matías A. Crosio, Ana V. Juárez, Natalia Wilke   +3 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Phosphate Metabolism [PDF]

Calcified Tissue International, 2020
Salvatore Minisola, Maria Luisa Brandi
openaire   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Calcium/strontium substituted phosphate based glasses for orthopaedic applications

, 2016
Uresha Patel, Kazi M. Zakir Hossain, Andrew Kennedy, Hannon Alex, Barney Emma, Ifty Ahmed   +5 more
openalex   +1 more source

Effect ofRhizobiumand Phosphate Solubilizing Bacterial Inoculants on Symbiotic Traits, Nodule Leghemoglobin, and Yield of Chickpea Genotypes [PDF]

, 2013
G. S. Tagore, S. L. Namdeo, Sanjay Sharma, Narendra Kumar   +3 more
openalex   +1 more source