Results 141 to 150 of about 4,841 (163)

Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis. [PDF]

Front Immunol
Yuan D, Qin H, Yu Z.
europepmc   +1 more source

Lipidomics reveals lipid changes in the hepatic during the late chick embryonic development. [PDF]

Poult Sci
Wang H, Wang Y, Liu J, Wu J, Hou Q, Ren Z, Liu Y, Yang X.   +7 more
europepmc   +1 more source

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production. [PDF]

J Lipid Res
Kasongo AA, Vijithakumar V, Abd-Elrahman KS, Prabhune R, Gharibeh L, Nadeau R, Robillard I, Spring S, Robichaud S, Asif S, Gibbings D, Moore KJ, Sled JG, Ruiz M, Lavallée-Adam M, Ferguson SSG, Lacoste B, Lagace DC, Ouimet M.   +18 more
europepmc   +1 more source

Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast. [PDF]

J Biol Eng
Saha TR, Kang NK, Lee EY.
europepmc   +1 more source

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Phosphatidylcholine-sterol O-acyltransferase

1996
Dietmar Schomburg, Dörte Stephan
openaire   +2 more sources

Sevoflurane attenuates proliferative and migratory activity of lung cancer cells via mediating the microRNA-100-3p/sterol O-Acyltransferase 1 axis

Chinese journal of physiology, 2023
Recently, evidence has shown that microRNA-100-3p (miR-100-3p) has been revealed as a tumor suppressor in diverse human diseases, while its capability in lung cancer warrants further validation. In this work, we aimed to discuss the impact of sevoflurane
Bicheng Fu, Fucheng Zhou, Jian Zhang, Xianglong Kong, Boxiong Ni, Jianlong Bu, Shidong Xu, Changjun He   +7 more
semanticscholar   +1 more source

Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential.

Journal of Medicinal Chemistry, 2022
Sterol O-acyltransferase (SOAT) is a membrane-bound enzyme that aids the esterification of cholesterol and fatty acids to cholesterol esters. SOAT has been studied extensively as a potential drug target, since its inhibition can serve as an alternative ...
Pinaki Bhattacharjee, Nicholas Rutland, Malliga R. Iyer   +2 more
semanticscholar   +1 more source

Abstract 5468: A pharmacological inhibition of sterol O-acyltransferase 1improves response to enzalutamide in prostate cancer

Cancer Research, 2022
Prostate cancer (PCa) growth is mediated by androgens via activation of androgen receptor (AR). Accordingly, androgen deprivation therapy (ADT) is the gold standard for the treatment of advanced PCa, but progression to castration-resistant PCa (CRPC ...
Sora Q. Kim, S. Utturkar, Nadia M. Atallah, Kee-Hong Kim   +3 more
semanticscholar   +1 more source

Targeting sterol O-acyltransferase 1 rewires fatty acid metabolism and uncovers immune vulnerability in hepatocellular carcinoma.

Hepatology
BACKGROUND AND AIMS The development of hepatocellular carcinoma (HCC) is intricately linked to metabolic processes and immune evasion strategies. As an emerging metabolic vulnerability in HCC, detailed molecular mechanisms of Sterol O-Acyltransferase 1 ...
Huanhuan Ma, Vanilla Xin Zhang, Y. Tsui, J. Lee, Eva K. Lee, Jingyi Lu, Huan Deng, Fan-Hong Zeng, DanielWai-Hung Ho, C. Hui, Abdullah Husain, K. Sze, Irene Oi-Lin Ng   +12 more
semanticscholar   +1 more source

Heterologous Biosynthesis of the Sterol O-Acyltransferase Inhibitor Helvamide Unveils an α-Ketoglutarate-Dependent Cross-Linking Oxygenase.

Organic Letters
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from the genome of Aspergillus rugulosus MST-FP2007. Heterologous expression of hvm in A.
Rui Wang, Jia-Jing Liang, Wen-Chia Yang, Daniel Vuong, J. Kalaitzis, Alastair E Lacey, Ernest Lacey, Andrew M. Piggott, Y. Chooi, Hang Li   +9 more
semanticscholar   +1 more source