Results 41 to 50 of about 4,293 (162)
iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency [PDF]
, 2005 Affiliation: CHU-Sainte-Justine, Université de MontréalTransport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are ...
Drouin, Éric +3 more
core +2 more sources
Experimental Physiology, EarlyView.Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood +8 more
wiley +1 more source
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer +20 more
wiley +1 more source
Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]
, 2009 We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni +79 more
core +3 more sources
Micrometer‐Sized Liposome‐Based Systems: A Hierarchical Breakdown
ChemSystemsChem, Volume 7, Issue 3, May 2025.Micrometer‐sized liposomes (MSLs) are gaining attention for various applications, from biophysical cell models to molecular robots. Despite their growing importance, reviews on MSLs across disciplines are scarce. This review fills the gap by providing a systematic overview of MSL design, from applications to functionalization and to formation, aimed at
Shogo Hamada +9 more
wiley +1 more source
, 2019 In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key ...
Hausser, A., von Blume, J.
core +1 more source
Differential Expression of Intestinal Genes in Opossums with High and Low Responses to Dietary Cholesterol [PDF]
, 2009 High and low responding opossums (Monodelphis domestica) differ in their plasma very low density lipoprotein and low density lipoprotein (VLDL+LDL) cholesterol
Chan, Jeannie +4 more
core +4 more sources
Drug‐Based Lifespan Extension in Mice Strongly Affects Lipids Across Six Organs
Aging Cell, Volume 24, Issue 5, May 2025.Using six interventions that have previously shown to differentially increase lifespan in male and female mice, we here show significant metabolic changes across organs, sex and metabolic pathways. Specifically, lipid responses were prominent across organs, but also in a sexually dimorphic manner.
Sara Greenfield +7 more
wiley +1 more source
Metabolism and Translocation of Aminophospholipids in Mammalian Cells [PDF]
, 2012 In this study we investigated the metabolism, i.e. remodeling and translocation, of the aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE). A new method for introduction of exogenous PS and PE molecular species to cultured cells
Kainu, Ville
core