Results 371 to 380 of about 363,126 (392)
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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.
Science, 1997Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase. Chromatographic separation of brain cytosol revealed a kinase activity that phosphorylated and activated PKB only in the presence ...
D. Stokoe +8 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2015
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to ...
M. Andrs +5 more
semanticscholar +1 more source
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to ...
M. Andrs +5 more
semanticscholar +1 more source
The Journal of Immunology, 1988
Abstract Phosphodiesteric cleavage of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) is required for transmembrane signaling by chemoattractants in human polymorphonuclear leukocytes (PMN). Considering the importance of PtdIns-4,5-P2 as a reservoir for second messenger substances, we have characterized the enzyme system that ...
M C, Pike, C, Arndt
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Abstract Phosphodiesteric cleavage of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) is required for transmembrane signaling by chemoattractants in human polymorphonuclear leukocytes (PMN). Considering the importance of PtdIns-4,5-P2 as a reservoir for second messenger substances, we have characterized the enzyme system that ...
M C, Pike, C, Arndt
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Cell Calcium, 1982
Recent years have seen a rapid accumulation of information which relates to the idea that receptor-controlled effects on inositol lipid metabolism might somehow be involved in the control of stimulated cells (see refs 1–14 for reviews). Most of these studies have been concerned only with phosphatidylinositol (PtdIns) and have tended to ignore the ...
Peter Downes, Robert H. Michell
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Recent years have seen a rapid accumulation of information which relates to the idea that receptor-controlled effects on inositol lipid metabolism might somehow be involved in the control of stimulated cells (see refs 1–14 for reviews). Most of these studies have been concerned only with phosphatidylinositol (PtdIns) and have tended to ignore the ...
Peter Downes, Robert H. Michell
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Metabolism of phosphatidylinositol in the frog retina
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980The synthesis and the turnover of phosphatidylinositol in frog retinal rod outer segments and microsomes were studied by following the time course of incorporation into lipids of the following radioactive precursors: [3H]glycerol, 33PO4, and [3H]inositol. 1.
Maureen B. Maude +2 more
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Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays
2013Inositol lipid kinases are perhaps the easiest and most straightforward enzymes in the phosphoinositide pathway to analyze. In addition to monitoring lipid kinase-specific activity, lipid kinase assays can be used to quantify the inositol lipids present in isolated membranes (Jones et al., Methods Mol Biol 462:75-88, 2009).
Wendy F. Boss +4 more
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The phosphatidylinositol response of chondrocytes in culture
Agents and Actions, 1989This study examined the phosphatidylinositol (PI) response in chondrocytes. The levels of 3H-inositol phosphates (IPs) were measured in guinea pig chondrocyte cultures labelled with 3H-myo-inositol and exposed to various inflammatory mediators and known agonists of the PI response, including bradykinin, carbachol, histamine, A23187, or recombinant ...
D. J. Schrier +2 more
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Synthesis of phosphatidylinositol mannosides (PIMs)
Carbohydrate Research, 2003Two strategies towards the synthesis of phosphatidylinositol mannosides (PIMs) were elaborated which permit selective access to the O-1-, O-2-, and the O-6 position of the myo-inositol residue. Starting materials are 1,2:5,6- and 1,2:4,5-di-O-cyclohexylidene-DL-myo-inositol, respectively.
Richard R. Schmidt, Andreas Stadelmaier
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Review of Phosphatidylinositol Phosphate Kinase in Phosphatidylinositol Signaling Pathway
2014Phosphatidylinositol signaling pathway is an important signal transduction pathway that plays critical roles in multiple cell processes first demonstrated in animal cells. Research evidences have shown that although not exactly the same as it is in yeast and mammalian cells, phosphatidylinositol signaling pathway also exists in plant cells and is ...
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Phosphatidylinositol phosphate kinases.
Journal of endocrinological investigation, 2004Phosphatidylinositol 4,5-bisphosphate is a multi-functional lipid, whose proposed functions now number more than twenty, covering many aspects of cell biology in several different subcellular compartments. The enzymes primarily responsible for synthesizing this lipid, the Type I phosphatidylinositol 4-phosphate 5-kinases, are therefore a tightly ...
Giudici, ML, Hinchliffe, KA, Irvine, RF
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