Results 261 to 270 of about 19,012 (341)

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia, Sumaira Pervaiz, Anna Klemmer, Malte Klüssendorf, Tobias Stauber   +4 more
wiley   +1 more source

Ergosterol-induced immune response in barley involves phosphorylation of phosphatidylinositol phosphate metabolic enzymes and activation of diterpene biosynthesis. [PDF]

New Phytol
Saake P, Brands M, Endeshaw AB, Stolze SC, Westhoff P, Balcke GU, Hensel G, Holton N, Zipfel C, Tissier A, Nakagami H, Zuccaro A.   +11 more
europepmc   +1 more source

Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. [PDF]

Mol Pharmacol, 2009
Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE.   +5 more
europepmc   +1 more source

Protein kinase‐independent activation of CFTR by phosphatidylinositol phosphates [PDF]

, 2004
Bettina Himmel, Georg Nagel
openalex   +1 more source

TP53‐Mutated Acute Myeloid Leukemia: Unanswered Questions

Hematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT TP53‐mutated acute myeloid leukemia (AML) remains one of the most treatment‐resistant hematologic malignancies, with poor overall survival despite advancements in therapeutic strategies. The loss of functional p53 compromises DNA repair, apoptosis, and genomic stability, rendering both conventional and novel therapies largely ineffective. This
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

The S1 helix is a VIP in VSP. [PDF]

J Gen Physiol
Short B.
europepmc   +1 more source

The Direct Interaction Between ASH2, a Drosophila Trithorax Group Protein, and SKTL, a Nuclear Phosphatidylinositol 4-Phosphate 5-Kinase, Implies a Role for Phosphatidylinositol 4,5-Bisphosphate in Maintaining Transcriptionally Active Chromatin [PDF]

, 2004
Mimi Cheng, Allen Shearn
openalex   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

The Mechanisms of Lithium Action: The Old and New Findings. [PDF]

Pharmaceuticals (Basel)
Sakrajda K, Rybakowski JK.
europepmc   +1 more source

Sorting nexin homologues are targets of phosphatidylinositol 3‐phosphate in sporulation of Schizosaccharomyces pombe [PDF]

, 2004
Takako Koga, Masayuki Onishi, Yoko Nakamura, Aiko Hirata, Taro Nakamura, Chikashi Shimoda, Tomoko Iwaki, Kaoru Takegawa, Yasuhisa Fukui   +8 more
openalex   +1 more source