Results 241 to 250 of about 133,958 (282)

Nuclear-Targeting Lipid PtIV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure.

Journal of the American Chemical Society, 2023
Patients treated with Pt-based anticancer drugs (PtII) often experience severe side effects and are susceptible to cancer recurrence due to the limited bioavailability of PtII and tumor-induced immunosuppression. The exposure of phosphatidylserine on the
Dengshuai Wei, Junning Fan, Jianqin Yan, Chaolong Liu, Jie Cao, Chun Xu, Yong Sun, Haihua Xiao   +7 more
semanticscholar   +1 more source

Phosphatidylserine Lipid Nanoparticles Promote Systemic RNA Delivery to Secondary Lymphoid Organs.

Nano letters (Print), 2022
Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various applications. While the current delivery method relies on the drainage of nanoparticles to lymph nodes by intramuscular (IM) or subcutaneous (SC) injections, an ...
Sijin Luozhong, Zhefan Yuan, Tara Sarmiento, Yu Chen, Wen-Tian Gu, Caleb McCurdy, Wenting Gao, Ruoxin Li, S. Wilkens, Shaoyi Jiang   +9 more
semanticscholar   +1 more source

Phosphatidylserine-mediated oral tolerance

Cellular Immunology, 2023
Phosphatidylserine (PS) is an anionic phospholipid exposed on the surface of apoptotic cells. The exposure of PS typically recruits and signals phagocytes to engulf and silently clear these dying cells to maintain tolerance via immunological ignorance.
Nhan H, Nguyen, Vincent, Chak, Katherine, Keller, Helen, Wu, Sathy V, Balu-Iyer   +4 more
openaire   +2 more sources

Phosphatidylserine in Diabetes Research

Molecular Pharmaceutics, 2022
Phospholipids are lipids that constitute the basic structure of cell membranes. In-depth research has shown that in addition to supporting cell structures, phospholipids participate in multiple cellular processes, including promoting cell signal transduction, guiding protein translocation, activating enzymatic activity, and eliminating dysfunctional ...
Dandan Xiao, Wenguang Chang
openaire   +2 more sources

Preparation of Phosphatidylserine

Nature, 1963
SEVERAL methods for the preparation1,2 or quantitative isolation3 of phosphatidylserine are now in existence. An investigation of some of the factors involved in the chromatography of phospholipids4,5 revealed the role of H+ ion exchange in the conversion of the salt form to the acidic form of phosphatidylserine on a silicic acid column.
L, RATHBONE, P M, MARONEY
openaire   +2 more sources

Phosphatidylserine decarboxylase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes. The cloned bacterial gene encodes an integral membrane protein that is first made as a proenzyme, and subsequently proteolyzed to an alpha subunit, containing a pyruvoyl prosthetic group, and a beta subunit. Two
openaire   +2 more sources

Exploiting Surface Phosphatidylserine

Science, 2008
Many animals use the presence of the phospholipid phosphatidylserine (PS), on the outer leaflet of the plasma membrane, as a way to recognize and destroy apoptotic cells by phagocytic engulfment. In this issue, two papers illustrate the differential roles played by PS in normal cells and during virus infection (see the Perspective by Fairn
L. Bryan Ray, Stella M. Hurtley
openaire   +2 more sources

Phosphatidylserine synthase from yeast

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
Whereas mammalian cells produce PS by a base exchange reaction from preexisting phospholipids, yeast cells synthesize PS from CDP-diacylglycerol and serine by the PS synthase reaction. Yeast PS synthase was purified to homogeneity and shown to have a molecular mass of 23 kDa. The activity is dependent on either Mg2+ or Mn2+ and Triton X-100. The enzyme
S, Yamashita, J, Nikawa
openaire   +2 more sources

Optimized synthesis of phosphatidylserine

Amino Acids, 2010
The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting ...
GUANTI, GIUSEPPE, BANFI, LUCA, BASSO, ANDREA, BONDANZA L, GUGLIERI G, POWLES K, RIVA, RENATA   +6 more
openaire   +2 more sources