Results 251 to 260 of about 133,958 (282)

Phosphatidylserine-Mediated Cellular Signaling

2013
Phosphatidylserine (PS), a phospholipid with a negatively charged head group, is an important constituent of eukaryotic membranes. Rather than being a passive component of cellular membranes, PS plays an important role in a number of signaling pathways.
Jason G, Kay, Sergio, Grinstein
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Phosphatidylserine synthase from bacteria

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
This review summarizes the characteristics of two subclasses of phosphatidylserine synthases: subclass I of gram-negative bacteria and subclass II of gram-positive bacteria. Unlike other phospholipid biosynthetic enzymes, the phosphatidylserine synthases of gram-negative bacteria, the enzyme from Escherichia coli has been extensively examined and ...
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Separation procedures for phosphatidylserines

Journal of Chromatography B: Biomedical Sciences and Applications, 1998
This paper reviews working procedures for the separation of phosphatidylserines (PS) in complex sample matrices. It begins with an introductory overview of important aspects of PS involvement in cellular lipid biochemistry. The main body of the review describes various procedures for the extraction, isolation, purification, and separation of the PS ...
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Phosphatidylserine and the human brain

Nutrition, 2015
The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function.A scientific literature search was conducted on MEDLINE for relevant articles regarding PS and the human brain published before June 2014. Additional publications
Michael J, Glade, Kyl, Smith
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Induction of Apoptosis by Phosphatidylserine

Journal of Biochemistry, 1998
Treatment of Chinese hamster ovary (CHO) cells with phosphatidylserine (PS) caused cell death in a dose-dependent manner. Other phospholipids, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid, had no effect on cell viability. The cells incubated with PS became round and underwent a dramatic reduction of
K, Uchida, K, Emoto, D L, Daleke, K, Inoue, M, Umeda   +4 more
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Pharmacological effects of phosphatidylserine liposomes

Nature, 1976
PHARMACOLOGICAL studies on diacylphospholipids develop along two lines of investigation. In the first, preparations of liposomes are used as carriers of drugs either bound to the bilayer or entrapped inside the vesicles. Sonicated liposomes have been shown to be able to transport inhibitors or drugs to target sites in vitro1 and in vivo2. In the second,
A, Bruni, G, Toffano, A, Leon, E, Boarato   +3 more
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Metabolism and functions of phosphatidylserine

Progress in Lipid Research, 2005
Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and enzymes that are involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells and discuss the available information on the regulation of PS biosynthesis in these organisms ...
Jean E, Vance, Rineke, Steenbergen
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Phosphatidylserine reverses reserpine-induced amnesia

European Journal of Pharmacology, 2000
The effects of phosphatidylserine (PS) were studied in rats treated with reserpine (1 mg/kg) immediately after training in the passive avoidance task. In experiment I, phosphatidylserine (25 mg/kg) was administered 30 min before or immediately after training.
Alves, CSD, Aldreatini, R., Cunha, C. da, Tufik, S., Vital, MABF   +4 more
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Phosphatidylserine promotes polar Cdc42 localization

Nature Cell Biology, 2011
The establishment and maintenance of cell polarity requires targeted recruitment of polarity regulators to the plasma membrane. Phosphatidylserine is now shown to have a key role in polarization of yeast cells and the localization of the central polarity regulator Cdc42.
Freisinger, T., Wedlich-Söldner, R.
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Phosphatidylserine Recruits Rac1

Science's STKE, 2006
Rac1 is a member of the Rho family of guanosine triphosphatases (GTPases) and is involved in stimulating membrane ruffling and cell migration. Finkielstein et al . show, using liposome-binding assays, nuclear magnetic resonance assays, and lipid overlay assays, that purified Rac1, either prenylated or nonprenylated,
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