Results 281 to 290 of about 10,007 (332)

The Genetic Factors Controlling the Accumulation of Amylase/Trypsin Inhibitors (ATIs) in Barley for Enhancing Human Nutrition and Health

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
ATIs in cereal seeds link to celiac disease, asthma, and immune response. Here, we report the first study exploring genetic factors affecting ATI levels in barley. GWAS identified multiple QTNs influencing ATI accumulation with notable variation. Eight QTNs are associated with lower ATI levels; a key gene was identified.
Dalia Z. Alomari, Samar G. Thabet, Mashael D. Alqahtani, Matías Schierenbeck, Sarah Joestl, Sabrina Geisslitz, Katharina A. Scherf, Andreas Börner, Ahmad M. Alqudah   +8 more
wiley   +1 more source

Plant Metabolome Between Root and Aerial Parts of <i>Cichorium intybus</i> L. and Anti-Hyperuricemia Mechanisms Based on Cell Metabolomics. [PDF]

Metabolites
Wang J, Shen S, Zhao Q, Shen X, Zhuo Q.
europepmc   +1 more source

MeMAGEN: A Phase IIa/IIb open‐label trial of memantine testing safety and tolerability in sickle cell patients

HemaSphere, Volume 10, Issue 1, January 2026.
ABSTRACT Administration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD). The objectives of the 1‐year dose‐escalation Phase IIa/IIb Memantine trial (MeMAGEN – NCT 03247218) with 17 SCD patients who were under stable ...
Ariel Koren, Carina Levin, Leonid Livshits, Fabio Valeri, Sari Peretz, Sivan Raz, Anna Yu Bogdanova, Max Gassmann   +7 more
wiley   +1 more source

Enhancing adipogenesis in Wharton's jelly multipotent mesenchymal stromal cells through lipidomic insights and fatty acid supplementation. [PDF]

Sci Rep
Rogulska O, Vavrinova E, Vackova I, Smolkova K, Petrenko Y.   +4 more
europepmc   +1 more source

Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic red blood cell (RBC) transfusion sustains patients with diverse hematologic disorders, but repeated transfusion leads to iron overload and alloimmunization. Reducing transfusion burden requires identifying donor units that circulate more effectively after storage, yet determinants of this variability remain incompletely defined.
James C. Zimring, Ariel M. Hay, Monika Dzieciatkowska, Daniel Stephenson, Zachary B. Haiman, Steven Kleinman, Philip J. Norris, Michael P. Busch, Nareg Roubinian, Elisa Fermo, Paola Bianchi, Gregory R. Keele, Grier P. Page, Angelo D'Alessandro   +13 more
wiley   +1 more source

Phenothiazine Derivatives and Their Impact on the Apoptosis Processes: A Review

Journal of Applied Toxicology, Volume 46, Issue 1, Page 42-60, January 2026.
ABSTRACT Phenothiazine derivatives have been used for decades as antipsychotic drugs in multiple mental health and physical conditions treatment (schizophrenia, mania in bipolar disorder, and psychosis). Epidemiological studies have shown that people with schizophrenia are less likely to suffer from cancer, which indicates the ability of antipsychotics
Michał Otręba, Łukasz Marek, Piotr Paduszyński, Jerzy Stojko, Anna Rzepecka‐Stojko   +4 more
wiley   +1 more source

Parkinson's Disease Through the Lens of Metabolomics: A Targeted Systematic Review on Human Studies (2019-2024). [PDF]

J Clin Med
Cannas F, Kopeć KK, Zuddas N, Cesare Marincola F, Arcara G, Loi M, Mussap M, Fanos V.   +7 more
europepmc   +1 more source

Lipidomic Comparison of Detergent‐Soluble and Detergent‐Resistant Lipid Domains Isolated From Rat Cerebellum and the Effect of Hypoxia–Ischemia Using UPLC‐HDMSE

Journal of Mass Spectrometry, Volume 61, Issue 1, January 2026.
ABSTRACT Hypoxic ischemic encephalopathy (HIE) due to insufficient oxygen or blood flow to the brain can result in inflammation, impaired neurodevelopment, or death. Changes to microdomain lipid composition may contribute to altered structure and function of key regulatory processes; however, knowledge regarding changes to membrane lipid composition ...
Samuel A. Krug, Min He, Ningfeng Tang, Cynthia Bearer, Maureen A. Kane   +4 more
wiley   +1 more source

Multi-Omics Deciphers Divergent Mechanisms in Differentially Cardiac-Remodeled Yili Horses Under Conditions of Equivalent Power Output. [PDF]

Animals (Basel)
Wang T, Yang X, Ren W, Meng J, Yao X, Chu H, Yao R, Zhai M, Zeng Y.   +8 more
europepmc   +1 more source

Analysis of triacylglycerol and phospholipid sn‐positional isomers by liquid chromatographic and mass spectrometric methodologies

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 4-36, January/February 2026.
Abstract Analysis of triacylglycerol (TG) and phospholipid sn‐positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods.
Mikael Fabritius, Baoru Yang
wiley   +1 more source