Results 301 to 310 of about 10,007 (332)
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Preparation of Phosphatidylserine
Nature, 1963SEVERAL methods for the preparation1,2 or quantitative isolation3 of phosphatidylserine are now in existence. An investigation of some of the factors involved in the chromatography of phospholipids4,5 revealed the role of H+ ion exchange in the conversion of the salt form to the acidic form of phosphatidylserine on a silicic acid column.
L, RATHBONE, P M, MARONEY
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Phosphatidylserine decarboxylase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes. The cloned bacterial gene encodes an integral membrane protein that is first made as a proenzyme, and subsequently proteolyzed to an alpha subunit, containing a pyruvoyl prosthetic group, and a beta subunit. Two
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Exploiting Surface Phosphatidylserine
Science, 2008Many animals use the presence of the phospholipid phosphatidylserine (PS), on the outer leaflet of the plasma membrane, as a way to recognize and destroy apoptotic cells by phagocytic engulfment. In this issue, two papers illustrate the differential roles played by PS in normal cells and during virus infection (see the Perspective by Fairn
L. Bryan Ray, Stella M. Hurtley
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Phosphatidylserine synthase from yeast
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997Whereas mammalian cells produce PS by a base exchange reaction from preexisting phospholipids, yeast cells synthesize PS from CDP-diacylglycerol and serine by the PS synthase reaction. Yeast PS synthase was purified to homogeneity and shown to have a molecular mass of 23 kDa. The activity is dependent on either Mg2+ or Mn2+ and Triton X-100. The enzyme
S, Yamashita, J, Nikawa
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Optimized synthesis of phosphatidylserine
Amino Acids, 2010The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting ...
GUANTI, GIUSEPPE +6 more
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Phosphatidylserine-Mediated Cellular Signaling
2013Phosphatidylserine (PS), a phospholipid with a negatively charged head group, is an important constituent of eukaryotic membranes. Rather than being a passive component of cellular membranes, PS plays an important role in a number of signaling pathways.
Jason G, Kay, Sergio, Grinstein
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Phosphatidylserine synthase from bacteria
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997This review summarizes the characteristics of two subclasses of phosphatidylserine synthases: subclass I of gram-negative bacteria and subclass II of gram-positive bacteria. Unlike other phospholipid biosynthetic enzymes, the phosphatidylserine synthases of gram-negative bacteria, the enzyme from Escherichia coli has been extensively examined and ...
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Separation procedures for phosphatidylserines
Journal of Chromatography B: Biomedical Sciences and Applications, 1998This paper reviews working procedures for the separation of phosphatidylserines (PS) in complex sample matrices. It begins with an introductory overview of important aspects of PS involvement in cellular lipid biochemistry. The main body of the review describes various procedures for the extraction, isolation, purification, and separation of the PS ...
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Phosphatidylserine and the human brain
Nutrition, 2015The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function.A scientific literature search was conducted on MEDLINE for relevant articles regarding PS and the human brain published before June 2014. Additional publications
Michael J, Glade, Kyl, Smith
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Induction of Apoptosis by Phosphatidylserine
Journal of Biochemistry, 1998Treatment of Chinese hamster ovary (CHO) cells with phosphatidylserine (PS) caused cell death in a dose-dependent manner. Other phospholipids, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid, had no effect on cell viability. The cells incubated with PS became round and underwent a dramatic reduction of
K, Uchida +4 more
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