Results 311 to 320 of about 10,007 (332)
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Pharmacological effects of phosphatidylserine liposomes
Nature, 1976PHARMACOLOGICAL studies on diacylphospholipids develop along two lines of investigation. In the first, preparations of liposomes are used as carriers of drugs either bound to the bilayer or entrapped inside the vesicles. Sonicated liposomes have been shown to be able to transport inhibitors or drugs to target sites in vitro1 and in vivo2. In the second,
A, Bruni +3 more
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Metabolism and functions of phosphatidylserine
Progress in Lipid Research, 2005Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and enzymes that are involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells and discuss the available information on the regulation of PS biosynthesis in these organisms ...
Jean E, Vance, Rineke, Steenbergen
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Phosphatidylserine reverses reserpine-induced amnesia
European Journal of Pharmacology, 2000The effects of phosphatidylserine (PS) were studied in rats treated with reserpine (1 mg/kg) immediately after training in the passive avoidance task. In experiment I, phosphatidylserine (25 mg/kg) was administered 30 min before or immediately after training.
Alves, CSD +4 more
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Phosphatidylserine promotes polar Cdc42 localization
Nature Cell Biology, 2011The establishment and maintenance of cell polarity requires targeted recruitment of polarity regulators to the plasma membrane. Phosphatidylserine is now shown to have a key role in polarization of yeast cells and the localization of the central polarity regulator Cdc42.
Freisinger, T., Wedlich-Söldner, R.
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Phosphatidylserine Recruits Rac1
Science's STKE, 2006Rac1 is a member of the Rho family of guanosine triphosphatases (GTPases) and is involved in stimulating membrane ruffling and cell migration. Finkielstein et al . show, using liposome-binding assays, nuclear magnetic resonance assays, and lipid overlay assays, that purified Rac1, either prenylated or nonprenylated,
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