Results 181 to 190 of about 2,886,292 (384)

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

Molecular Mechanisms Involved in Neural Substructure Development during Phosphodiesterase Inhibitor Treatment of Mesenchymal Stem Cells. [PDF]

Int J Mol Sci, 2020
Fajardo J, Milthorpe BK, Santos J.
europepmc   +1 more source

Effects of cyclic adenosine 3,5-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. [PDF]

, 1982
As a test of the hypothesis that cyclic nucleotides play a role in the regulation of retinomotor movements and disc shedding in the photoreceptor-pigment epithelial complex, we have used an in vitro eyecup preparation that sustains both disc shedding and
Besharse, J, BURNSIDE, Beth, Dunis, D
core   +1 more source

Management Strategies for Generalised Granuloma Annulare: A Systematic Review of Current and Emerging Therapies

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Generalised Granuloma Annulare (GGA) is a chronic inflammatory skin disorder with no standard treatment. Since the last review in 2013, new treatments and varied responses have highlighted the need for an updated synthesis to guide clinical decisions.
Luca Bettolini, Vincenzo Maione, Andrea Carugno, Giorgio Stabile, Antonio Podo Brunetti, Zeno Fratton, Enzo Errichetti, Nicola Zerbinati, Franco Rongioletti, Piergiacomo Calzavara‐Pinton, Mariateresa Rossi, Stefano Bighetti   +11 more
wiley   +1 more source

Surface Binding Energy Landscapes Affect Phosphodiesterase Isoform-Specific Inhibitor Selectivity

Computational and Structural Biotechnology Journal, 2019
As human phosphodiesterase (PDE) proteins are attractive drug targets, a large number of selective PDE inhibitors have been developed. However, since the catalytic sites of PDE isoforms are conserved in sequence and structure, it remains unclear how ...
Qing Liu, Andreas Herrmann, Qiang Huang
doaj  

Isolation and characterization of PDE-I and II, the inhibitors of cyclic adenosine-3',5'-monophosphate phosphodiesterase.

, 1978
Yûji Enomoto, Yoshio Furutani, HIROSHI NAGANAWA, MASA HAMADA, TOMIO TAKEUCHI, HAMAO UMEZAWA   +5 more
openalex   +2 more sources

Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults.

Journal of American Academy of Dermatology, 2016
A. Paller, W. Tom, M. Lebwohl, R. Blumenthal, M. Boguniewicz, R. Call, L. Eichenfield, D. Forsha, W. Rees, E. Simpson, M. Spellman, L. S. Stein Gold, A. Zaenglein, Matilda H. Hughes, L. Zane, A. Hebert   +15 more
semanticscholar   +1 more source

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Forssmann, W. G., Jonas, Udo, Meyer, M. F., Schulz-Knappe, P., Stief, Christian Georg, Taher, A., Truss, Michael C.   +6 more
core   +1 more source

Persistent activation of transducin by bleached rhodopsin in salamander rods. [PDF]

, 1996
The hydrolysis-resistant GTP analogue GTP-gamma-S was introduced into rods isolated from the retina of the salamander Ambystoma tigrinum to study the origin of the persistent excitation induced by intense bleaching illumination.
Cornwall, MC, Fain, GL, Matthews, HR
core  

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source