Results 231 to 240 of about 2,886,292 (384)

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin‐2 release from murine splenocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer [PDF]

, 1997
John E. Souness, Clare Houghton, Nughat Sardar, Michael T. Withnall   +3 more
openalex   +1 more source

A phase IIb single‐center study to assess the efficacy of apremilast for the treatment of nummular eczema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background The pathogenesis of nummular eczema (NE) remains unclear, and no targeted therapy has been approved. Apremilast is a small molecule inhibitor targeting phosphodiesterase‐4. Patients and Methods A phase IIb randomized, double‐blind, placebo‐controlled study evaluating the effects of apremilast or placebo in patients with NE.
Alexander Böhner, Peter Seiringer, Viktoria Kleeberger, Danielle Rogner, Christian Oesterlin, Tilo Biedermann, Kilian Eyerich, Felix Lauffer   +7 more
wiley   +1 more source

First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry

European Journal of Clinical Investigation, EarlyView.
Primary heart involvement (pHI) is a severe but often overlooked complication of systemic sclerosis (SSc), linked to heart failure, arrhythmias and mortality. In a study of 600 patients from the Italian SPRING‐SIR registry, 25% had ECG or echocardiographic signs of pHI at baseline, associated with older age, diffuse skin disease and intestinal symptoms.
Antonio Tonutti, Francesca Motta, Rossella De Angelis, Edoardo Cipolletta, Clodoveo Ferri, Gianluigi Bajocchi, Silvia Bellando‐Randone, Cosimo Bruni, Martina Orlandi, Giovanni Zanframundo, Rosario Foti, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Fabio Cacciapaglia, Giuseppe Murdaca, Giuseppina Abignano, Giorgio Pettiti, Alessandra Della Rossa, Maurizio Caminiti, Anna Maria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Luca Idolazzi, Marta Saracco, Cecilia Agnes, Corrado Campochiaro, Marco Fornaro, Federica Lumetti, Amelia Spinella, Luca Magnani, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Carlo Iandoli, Antonietta Gigante, Greta Pellegrino, Erika Pigatto, Maria Grazia Lazzaroni, Enrico De Lorenzis, Gianna Mennillo, Marco Di Battista, Giuseppa Pagano‐Mariano, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D'Angelo, Franco Cozzi, Franco Franceschini, Serena Guiducci, Lorenzo Dagna, Andrea Doria, Dilia Giuggioli, Valeria Riccieri, Carlo Salvarani, Florenzo Iannone, Marco Matucci‐Cerinic, Carlo Selmi, Maria De Santis, on behalf of SPRING‐SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society for Rheumatology), Giorgio Amato, Alessia Benenati, Francesca Calabrese, Renato Carignola, Francesca Dall’Ara, Angelo De Cata, Claudio Di Vico, Marica Doveri, Nicoletta Romeo, Elena Generali, Gianluca Sambataro, Rossella Talotta, Alberto Lo Gullo, Carlo Scirè, Greta Carrara, Giampiero Landolfi, Davide Rozza, Anna Zanetti   +91 more
wiley   +1 more source

A developmentally regulated and cAMP-repressible gene of Dictyostelium discoideum: cloning and expression of the gene encoding cyclic nucleotide phosphodiesterase inhibitor

, 1990
Lin Wu, Jakob Franke
openalex   +1 more source

Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma? [PDF]

, 1996
Gordon Dent, M A Giembycz
openalex   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Effect of phosphodiesterase inhibitor on diabetic nephropathy. [PDF]

Korean J Intern Med, 2012
Kang SW.
europepmc   +1 more source

Substituted 1,8-Naphthyridin-2(1H)-ones as Selective Phosphodiesterase IV Inhibitors.

, 1994
Akihiro Matsuura, Naoki Ashizawa, Reiji Asakura, T Kumonaka, T Aotsuka, Tadashi Hase, Chikako Shimizu, T. KURIHARA, F. Kobayashi   +8 more
openalex   +2 more sources

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source