Results 231 to 240 of about 2,974,682 (398)

Roflumilast in Dermatology: A Newer Phosphodiesterase-4 Inhibitor

Indian Journal of Dermatology
Suvesh Singh, Debopriya Paul, Aditi Snehal   +2 more
doaj   +1 more source

Erectile potentials of a new phosphodiesterase type 5 inhibitor, DA-8159, in diet-induced obese rats

, 2006
Jae-Young Yu, Kyung-Koo Kang, Moohi Yoo
openalex   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Activation of protein kinase A stimulates the progesterone-induced calcium influx in human sperm exposed to the phosphodiesterase inhibitor papaverine.

Journal of Andrology, 2008
V. Torres-Flores, Y. Hernández-Rueda, Paloma del Carmen Neri-Vidaurri, F. Jiménez-Trejo, Víctor Calderón-Salinas, J. Molina-Guarneros, M. González-Martínez   +6 more
semanticscholar   +1 more source

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Phosphodiesterase Inhibitors for Pulmonary Hypertension [PDF]

New England Journal of Medicine, 2010
GALIE', NAZZARENO, Rubin LJ, Simonneau G.   +2 more
openaire   +1 more source

The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction. [PDF]

Asian J Androl, 2019
Cho MC, Lee J, Park J, Oh S, Chai JS, Son H, Paick JS, Kim SW.   +7 more
europepmc   +1 more source

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase

, 1998
Allen J. Duplantier, Catharine J. Andresen, John B. Cheng, Victoria L. Cohan, Christian Decker, Frank M. DiCapua, Kenneth G. Kraus, Kerry L. Johnson, Claudia R. Turner, John P. Umland, J. W. Watson, Ronald T. Wester, Alison S. Williams, John A. Williams   +13 more
openalex   +1 more source

The phosphodiesterase 4 inhibitor AA6216 suppresses activity of fibrosis-specific macrophages

, 2021
Takashi Matsuhira, Osamu Nishiyama, Yuji Tabata, Shinji Kurashimo, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda   +6 more
openalex   +1 more source

Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation

The FEBS Journal, EarlyView.
The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott, Jui‐Hung Weng, Valeria Pane, Yuliang Ma, Jian Wu, Susan S. Taylor, Friedrich W. Herberg   +6 more
wiley   +1 more source