Results 271 to 280 of about 2,886,292 (384)

A phosphodiesterase inhibitor, cilostazol, prevents the onset of silent brain infarction in Japanese subjects with Type II diabetes

Diabetologia, 2002
T. Shinoda-Tagawa, Y. Yamasaki, Shigeru Yoshida, Y. Kajimoto, Takafumi Tsujino, N. Hakui, M. Matsumoto, M. Hori   +7 more
semanticscholar   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Molecular Approaches to Treating Chronic Obstructive Pulmonary Disease: Current Perspectives and Future Directions. [PDF]

Int J Mol Sci
Vu SP, Veit K, Sadikot RT.
europepmc   +1 more source

Rolipram, a Phosphodiesterase-4-Selective Inhibitor, Promotes the Survival of Cultured Rat Dopaminergic Neurons.

, 1997
Nobuyuki Yamashita, Akiko Hayashi, Jun Baba, Aiko Sawa   +3 more
openalex   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Management of treatment-resistant acquired perforating dermatosis with apremilast: A novel therapeutic approach. [PDF]

JAAD Case Rep
Zaidi H, Khan A, Sinha S, Sloan B, Aiudi D, Weston G.   +5 more
europepmc   +1 more source

Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types

The Journal of Physiology, EarlyView.
Abstract figure legend Photoreceptor loss has heterogeneous effects on functional retinal ganglion cell (RGC) types. A, illustrations of cross‐sections of rd10 retinae at different time points during degeneration. Left: P30, rod degeneration has commenced, cones are still unaffected.
Nadine Dyszkant, Jonathan Oesterle, Yongrong Qiu, Merle Harrer, Timm Schubert, Dominic Gonschorek, Thomas Euler   +6 more
wiley   +1 more source

Effect of Cilostazol, a Cyclic AMP Phosphodiesterase Inhibitor, on the Proliferation of Rat Aortic Smooth Muscle Cells in Culture

Journal of Cardiovascular Pharmacology, 1992
Sadao Takahashi, K. Oida, R. Fujiwara, H. Maeda, S. Hayashi, H. Takai, T. Tamai, T. Nakai, S. Miyabo   +8 more
semanticscholar   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source