Results 111 to 120 of about 21,592 (215)

Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data

Cell Reports, 2014
Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored.
Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, Shinya Kuroda   +17 more
doaj   +1 more source

Targeting cancer cell metabolism in pancreatic adenocarcinoma. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent need to explore innovative treatment strategies.
Cohen, R., de Gramont, A., Faivre, S., Neuzillet, C., Raymond, E., Tijeras-Raballand, A.   +5 more
core   +2 more sources

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Exploring the impact of elevated muscle temperature on the rate and extent of postmortem pH decline in porcine skeletal muscle [PDF]

, 2018
When an animal is harvested for meat, the resulting carcass is processed to provide safe and wholesome meat products for the consumer. One of these processing steps for pigs known as scalding involves heating the carcass in hot water (60ºC) in order to ...
Montgomery, Madison
core  

Multi‐Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates

Plant Biotechnology Journal, EarlyView.
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang, Jiying Li, Zhang Wang, Miao Yu, Chang Liu, Dongye Liu, Ruohan Wang   +6 more
wiley   +1 more source

The Impact of the Natural Grass-Growing Model on the Development of Korla Fragrant Pear Fruit, as Well as Its Influence on Post-Harvest Sugar Metabolism and the Expression of Key Enzyme Genes Involved in Fruit Sugar Synthesis

Agriculture
In this study, the effects of natural grass cultivation and clear cultivation on the physiological characteristics of Korla fragrant pear during fruit development and storage were investigated, providing a scientific basis for high-quality fragrant pear ...
Mingyang Yu, Lanfei Wang, Yan Chen, Weifan Fan, Hao Wang, Kailu Guo, Shutian Tao, Xin Gong, Jianping Bao   +8 more
doaj   +1 more source

Effects of hypo O-GlcNAcylation on Drosophila development [PDF]

, 2018
Post-translational modification of serine/threonine residues in nucleocytoplasmic proteins with N-acetylglucosamine (OGlcNAcylation) is an essential regulatory mechanism in many cellular processes.
Andrew T. Ferenbach, Baena-Lopez, Barrangou, Bassett, Bassett, Biryukova, Bond, Bouazzi, Brennan, Buse, Capotosti, Capotosti, Chou, Chu, Culí, Daan M.F. van Aalten, Daniel Mariappa, Doudna, Douris, Dura, Erickson, Furrer, Gambetta, Gambetta, Gantz, García-Bellido, Gratz, Gratz, Guinez, Hart, Hart, Hartenstein, Hu, Huang, Hwang, Ingham, Jang, Jinek, Julien, Kazemi, Kenwrick, Kristie, Lim, Lin, Liu, Mao, Mariappa, Mariappa, Müller, Niranjan, O'Donnell, Olivier-Van Stichelen, Parker, Pfaffl, Prescott, Radermacher, Rodriguez-Jato, Romani, Ruan, Selvan, Shafi, Sheldon, Sinclair, Sohn, Swamy, Treisman, Tyagi, Vella, Wang, Webster, Yi, Yin, Yu, Zachara, Zachara, Zhu, Zimmer   +76 more
core   +3 more sources

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, EarlyView.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core  

Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. [PDF]

, 2020
Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, renal,
Gomes, Aldrin V, Mishra, Manish, Newens, Joanne L, Phinney, Brett S, Salemi, Michelle R, Tiwari, Shuchita   +5 more
core