Results 121 to 130 of about 20,352 (205)

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

open access: yesInternational Journal of COPD, 2016
Ulrik Winning Iepsen,1 Gregers Druedal Wibe Munch,1 Mette Rugbjerg,1 Anders Rasmussen Rinnov,1 Morten Zacho,1 Stefan Peter Mortensen,1,2 Niels H Secher,3 Thomas Ringbaek,4 Bente Klarlund Pedersen,1 Ylva Hellsten,5 Peter Lange,1,4,6 Pia Thaning1,4 1The ...
Iepsen UW   +11 more
doaj  

The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis

open access: yesBioactive Materials, 2022
Understanding mechanisms underlying the heterogeneity of multipotent stem cells offers invaluable insights into biogenesis and tissue development. Extracellular matrix (ECM) stiffness has been acknowledged as a crucial factor regulating stem cell fate ...
Zheng Li   +6 more
doaj  

Detection of Mycobacterium lepromatosis in patients with leprosy in India

open access: yesInfection and Drug Resistance, 2018
Madhvi Ahuja,1,* Mallika Lavania,1,* Itu Singh,1 Ravindra P Turankar,1 Seema Chhabra,2 Tarun Narang,3 Sunil Dogra,3 Utpal Sengupta1 1Department of Molecular Biology, Stanley Browne Laboratory, TLM Community Hospital, Delhi, India; 2Department of ...
Ahuja M   +7 more
doaj  

p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP

open access: yesCell Reports, 2023
Summary: Aerobic glycolysis is critical for cancer progression and can be exploited in cancer therapy. Here, we report that the human carboxymethylenebutenolidase homolog (carboxymethylenebutenolidase-like [CMBL]) acts as a tumor suppressor by ...
Yingdan Huang   +10 more
doaj  

Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation

open access: yesNature Communications
Innate immune responses are linked to key metabolic pathways, yet the proximal signaling events that connect these systems remain poorly understood. Here we show that phosphofructokinase 1, liver type (PFKL), a rate-limiting enzyme of glycolysis, is ...
Meiyue Wang   +17 more
doaj   +1 more source

Changes in expression of genes related to glucose metabolism in liver and skeletal muscle of rats exposed to acute hypoxia

open access: yesHeliyon, 2020
The aim of this study was to determine changes in gene expression associated with glucose metabolism in the liver and soleus muscles of rats exposed to hypoxia to improve work capacity under high altitude conditions.
Yurie Hara, Nakamichi Watanabe
doaj  

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]

open access: yes, 2019
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core  

Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation.

open access: yesJournal of Lipid Research, 1979
Glucagon and N,(6)O(2)-dibutyryl cyclic adenosine 3‘,5‘-cyclic monophosphate (Bt(2)cAMP) inhibit fatty acid synthesis from acetate by more than 90% and prevent citrate formation in chick hepatocytes metabolizing glucose.
S D Clarke, P A Watkins, M D Lane
doaj  

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