Results 51 to 60 of about 20,352 (205)

Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

Frontiers in Immunology, 2021
Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction.
Jianlin Zuo, Jinshuo Tang, Meng Lu, Zhongsheng Zhou, Yang Li, Hao Tian, Enbo Liu, Baoying Gao, Te Liu, Pu Shao, Pu Shao   +10 more
doaj   +1 more source

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]

, 2019
Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M, Mackenzie, Gerardo G, Wang, Yuefei, Wei, Ran   +3 more
core   +1 more source

Phosphorylation of Bad at Thr-201 by JNK1 Promotes Glycolysis through Activation of Phosphofructokinase-1 [PDF]

Journal of Biological Chemistry, 2008
The mitogen-activated protein kinase JNK1 suppresses interleukin-3 withdrawal-induced cell death through phosphorylation of the BH3-only pro-apoptotic Bcl-2 family protein Bad at Thr-201. It is unknown whether JNK1 regulates glycolysis, an important metabolic process that is involved in cell survival, and if so, whether the regulation depends on Thr ...
Hongbin Deng, Fei Yu, Jian‐Qun Chen, Yingming Zhao, Jialing Xiang, Anning Lin   +5 more
openalex   +4 more sources

Genome-Wide Identification and Expression Analysis Elucidates the Potential Role of PFK Gene Family in Drought Stress Tolerance and Sugar Metabolism in Cotton

Frontiers in Genetics, 2022
Drought has been identified as a major threat for global crop production worldwide. Phosphofructokinase (PFK) is vital for sugar metabolism. During phosphorylation, plants have two enzymes: ATP-dependent phosphofructokinase (PFK) and pyrophosphate ...
Teame Gereziher Mehari, Yanchao Xu, Muhammad Jawad Umer, Fang Hui, Xiaoyan Cai, Zhongli Zhou, Yuqing Hou, Kai Wang, Baohua Wang, Fang Liu, Fang Liu   +10 more
doaj   +1 more source

The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

Diabetology & Metabolic Syndrome, 2023
Background Sodium-glucose cotransporter (SGLT)2 inhibitors have displayed beneficial effects on the cardiovascular system in diabetes mellitus (DM) patients.
Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi   +14 more
doaj   +1 more source

Identification of three gene families coordinating the conversion between fructose-6-phosphate and fructose-1,6-bisphosphate in wheat

Biologia Plantarum, 2021
Saccharides are a direct energy source for most organisms and the primary components in grains of common wheat (Triticum aestivum L., 2n = 6x = 42, AABBDD).
C.M. YU, Y.C. KE, K.P. ZHANG, M. YAN, H.R. JIN, Y.H. CHEN, J. ZHANG   +6 more
doaj   +1 more source

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)

Cancer & Metabolism, 2020
Background High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic ductal adenocarcinoma (PDAC ...
D. A. Richardson, P. Sritangos, A. D. James, A. Sultan, J. I. E. Bruce   +4 more
doaj   +1 more source

Modulation of glycolisis and the pentose phosphate pathway influences porcine oocyte in vitro maturation [PDF]

, 2013
Glycolytic and pentose phosphate pathway (PPP) activities were modulated in porcine cumulus-oocyte complexes (COCs) during in vitro maturation (IVM) by the addition of inhibitors or stimulators of key enzymes of the pathways to elucidate their relative ...
Alvarez, Gabriel Martín, Cetica, Pablo Daniel, Dalvit, Gabriel Carlos, Ferretti, E. L., Gutnisky, Cynthia   +4 more
core   +2 more sources

Distribution of nesfatin-1 expression in Bactrian camels and its impact on adipocyte glucose metabolism [PDF]

Pesquisa Veterinária Brasileira
: The study aimed to investigate the distribution and expression of nesfatin-1 in Bactrian camels and its impact on adipocyte glucose metabolism. Polyclonal antibodies against a single antigenic epitope of NUCB2/nesfatin-1 protein were prepared. Nesfatin-
Siriguleng Yu, Bijun Chen, Haoyu Bai, Ziyi Li, Yaru Niu, Xingchuan He, Wen Yu, Shumin Du, Junjian Jin, Hongqiang Yao   +9 more
doaj   +1 more source

Metabolic adaptations in skeletal muscle after 84 days of bed rest with and without concurrent flywheel resistance exercise [PDF]

, 2017
As metabolic changes in human skeletal muscle after long-term (simulated) spaceflight are not well understood, this study examined the effects of long-term microgravity, with and without concurrent resistance exercise, on skeletal muscle oxidative and ...
Cadefau, Joan A., Cussó, Roser, Fernandez-Gonzalo, Rodrigo, Guerrero, Mario, Irimia, José M., Rodriguez-Miquelez, Paula, Tesch, Per A.   +6 more
core   +1 more source