Results 11 to 20 of about 17,774 (212)

Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function [PDF]

Cell Reports, 2021
Summary: Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide adenine
Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.-M. Fan, Pankaj Seth   +7 more
doaj   +2 more sources

Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism [PDF]

Biology, 2021
The pentose phosphate pathway (PPP) plays an essential role in the metabolism of breast cancer cells for the management of oxidative stress and the synthesis of nucleotides.
Ibrahim H. Polat, Míriam Tarrado-Castellarnau, Rohit Bharat, Jordi Perarnau, Adrian Benito, Roldán Cortés, Philippe Sabatier, Marta Cascante   +7 more
doaj   +2 more sources

Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer [PDF]

Frontiers in Pharmacology, 2017
Cisplatin (DDP) is currently one of the most commonly used chemotherapeutic drugs for treating ovarian and lung cancer. However, resistance to cisplatin is common and it often leads to therapy failure.
Wujian Zheng, Qi Feng, Jiao Liu, Yanke Guo, Lvfen Gao, Ruiman Li, Meng Xu, Guizhen Yan, Zhinan Yin, Shuai Zhang, Shuangping Liu, Changliang Shan   +11 more
doaj   +2 more sources

Integrated amplification of NADPH-regenerating modules enhances cytidine biosynthesis in Escherichia coli [PDF]

Synthetic and Systems Biotechnology
In Escherichia coli, cofactor imbalance serves as a crucial limiting factor in cytidine biosynthesis, with nicotinamide adenine dinucleotide phosphate (NADPH) insufficiency representing the principal metabolic barrier.
Lu Liu, Xiangjun Zhang, Tengteng Zhu, Tong Ye, Zongqian Li, Wei Ding, Huiyan Liu, Haitian Fang   +7 more
doaj   +2 more sources

Dehydrogenaze polymorphism as a tool for early selection of low vigour rootstock for sweet and sour cherry [PDF]

Journal of Agricultural Sciences (Belgrade), 2017
The correlation of dehydrogenase isoenzyme profile with plant/tree vigour of twenty genotypes belonging to the genus Prunus and the subgenus Cerasus as well as to four commercial rootstocks (Colt, Gisela 5, Gisela 6 and MaxMa 14) was ...
Čolić Slavica D., Rakonjac Vera S., Nikolić Dragan T., Fotirić-Akšić Milica M.   +3 more
doaj   +1 more source

Peculiarities of glucose and glycerol metabolism in Nocardia vaccinii IMB B-7405 [PDF]

The Ukrainian Biochemical Journal, 2015
It has been established that in cells of Nocardia vaccinii IMB B-7405 (surfactant producer) glucose catabolism is performed through pentose phosphate cycle as well as through gluconate (activi­ty of NAD+-dependent glucose-6- phosphate dehydrogenase and ...
T. P. Pirog, T. A. Shevchuk, K. A. Beregova, N. V. Kudrya   +3 more
doaj   +1 more source

Serendipitous Discovery of a Competitive Inhibitor of FraB, a Salmonella Deglycase and Drug Target

Pathogens, 2022
Although salmonellosis, an infectious disease, is a significant global healthcare burden, there are no Salmonella-specific vaccines or therapeutics for humans. Motivated by our finding that FraB, a Salmonella deglycase responsible for fructose-asparagine
Pankajavalli Thirugnanasambantham, Sravya Kovvali, Austin Cool, Yuan Gao, Anice Sabag-Daigle, Erin F. Boulanger, Mark Mitton-Fry, Angela Di Capua, Edward J. Behrman, Vicki H. Wysocki, Steffen Lindert, Brian M. M. Ahmer, Venkat Gopalan   +12 more
doaj   +1 more source

Structure, kinetic characterization and subcellular localization of the two ribulose 5-phosphate epimerase isoenzymes from Trypanosoma cruzi [PDF]

, 2017
The enzyme of the pentose phosphate pathway (PPP) ribulose-5-phosphate-epimerase (RPE) is encoded by two genes present in the genome of Trypanosoma cruzi CL Brener clone: TcRPE1 and TcRPE2. Despite high sequence similarity at the amino acid residue level,
Cazzulo, Juan Jose, Delfino, Jose Maria, Gonzalez, Soledad Natalia, Maugeri, Dante, Valsecchi, Wanda Mariela   +4 more
core   +16 more sources

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels. [PDF]

Cell Chem Biol, 2019
Li H, Ericsson M, Rabasha B, Budnik B, Chan SH, Freinkman E, Lewis CA, Doench JG, Wagner BK, Garraway LA, Schreiber SL.   +10 more
europepmc   +2 more sources

Geobacillus stearothermophilus6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2009
Two crystal structures of recombinant Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase (Gs6PDH) in complex with the substrate 6-phosphogluconate have been determined at medium resolution. Gs6PDH shares significant sequence identity and structural similarity with the enzymes from Lactococcus lactis, sheep liver and the protozoan parasite ...
Cameron, Scott, Martini, Viviane P., Iulek, Jorge, Hunter, William N.   +3 more
openaire   +3 more sources