Results 321 to 330 of about 369,030 (389)

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Nearly T2T, phased genome assemblies of corals reveal haplotype diversity and the evolutionary process of gene expansion. [PDF]

DNA Res
Takeuchi T, Suzuki Y, Shoguchi E, Fujie M, Kawamitsu M, Shinzato C, Satoh N, Myers EW.   +7 more
europepmc   +1 more source

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

Cell Proliferation, EarlyView.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan   +7 more
wiley   +1 more source

Effect of puerarin administration on serum NOD-like receptor protein 3 (NLRP3) inflammasome, C1Q/TNF-related protein 3 (CTRP3) and lipoprotein-associated phospholipase 2 (LP-PLA2) levels. [PDF]

J Med Biochem
Wang G, Tang Q, Wang D.
europepmc   +1 more source

Genetic variation in zoophagy and dietary shift in the phytozoophagous tarnished plant bug, Lygus lineolaris

Entomologia Experimentalis et Applicata, EarlyView.
Phytozoophagous insects such as Lygus lineolaris feed on plants and prey. This study assessed the genetic variability and heritability of zoophagy and dietary shift in 15 isofemale lines with access to Ephestia kuehniella eggs and with or without access to plant resources.
François Dumont, Mireia Solà Cassi, Caroline Provost   +2 more
wiley   +1 more source

Cerebrovascular events induced by venomous snake bites: A systematic review. [PDF]

Heliyon
Vasconez-Gonzalez J, Delgado-Moreira K, Izquierdo-Condoy JS, de Lourdes Noboa-Lasso M, Gamez-Rivera E, Lopez-Molina MB, López-Cortés A, Tello-De-la-Torre A, Cerda AT, Martinod DS, Ortiz-Prado E.   +10 more
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Phospholipase A₂ from <i>Daboia siamensis</i> venom induces acute kidney injury: involvement of ion channels in an isolated perfused rabbit kidney model. [PDF]

J Venom Anim Toxins Incl Trop Dis
Chaiyabutr N, Vasaruchapong T, Laoungbua P, Khow O, Chanhome L, Sitprija V.   +5 more
europepmc   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization

The FEBS Journal, EarlyView.
Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun, So Young Lee, Shin‐Young Park, Joong Sub Choi, Mee‐Sup Yoon, Joong‐Soo Han   +5 more
wiley   +1 more source