Results 41 to 50 of about 379,007 (338)

Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus [PDF]

, 2017
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria.
Alvarez, Silvia, Astiz, Mariana, Imsen, Mercedes, Magnani, Natalia Daniela, Merino, Florencia, Reines, Analia Gabriela, Seilicovich, Adriana, Zarate, Sandra Cristina   +7 more
core   +2 more sources

Antioxidant Activity in Vitro of Antarctic Krill Phospholipids and Its Anti-aging Effect on Caenorhabditis elegans [PDF]

Shipin Kexue
In order to explore the antioxidant and anti-aging effects and underlying mechanism of Antarctic krill phospholipids, the antioxidant capacity in vitro of krill phospholipids was evaluated by radical scavenging capacities against 1, 1-diphenyl-2 ...
JIAN Peiyi, FENG Mingxi, CHEN Rong, TANG Lei, ZHENG Jinluan, ZHAO Lichao
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Comparative evaluation of the micelle formation process of phospolipids of rapeseed and sunflower lecithines in nonpolar solvents

Новые технологии, 2019
It is known that the ability of phospholipids in plant lecithins to micelle formation in solutions of non-polar solvents depends on their chemical composition.
E. P. Victorova, E. V. Lisovaya, O. S. Agafonov, V. I. Martovshchuk   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Thermodynamic Approach to Phase Coexistence in Ternary Phospholipi-Cholesterol Mixtures

, 2011
We introduce a simple and predictive model for determining the phase stability of ternary phospholipid-cholesterol mixtures. Assuming that competition between the liquid and gel order of the phospholipids is the main driving force behind lipid ...
Marques, Carlos M., Thalmann, Fabrice, Wolff, Jean   +2 more
core   +3 more sources

Metabolic Effects of Bariatric Surgery in Mouse Models of Circadian Disruption [PDF]

, 2015
Background/Objectives: Mounting evidence supports a link between circadian disruption and metabolic disease. Humans with circadian disruption (for example, night-shift workers) have an increased risk of obesity and cardiometabolic diseases compared with ...
Arble, Deanna M., Sandoval, Darleen A., Seeley, Randy J., Turek, Fred W., Woods, Stephen C.   +4 more
core   +3 more sources

INVESTIGATION ON THE MORPHOLOGY AND PROPERTIES OF AGGREGATE STRUCTURES OF NATURAL PHOSPHOLIPIDS IN AQUEOUS SYSTEM USING CRYO-TEM

Indonesian Journal of Chemistry, 2012
Cryogenic transmission electron microscopy (Cryo-TEM) was used to investigate the aggregates morphology and properties of candle tree (Aleurites moluccana) endosperm, sesame (Sesamum indicum L.
Dwi Hudiyanti, Tri Joko Raharjo, Narsito Narsito, Sri Noegrohati   +3 more
doaj   +1 more source

Lipidome Profiling of Phosphorus Deficiency-Tolerant Rice Cultivars Reveals Remodeling of Membrane Lipids as a Mechanism of Low P Tolerance

Plants, 2023
Plants have evolved various mechanisms for low P tolerance, one of which is changing their membrane lipid composition by remodeling phospholipids with non-phospholipids.
Soichiro Honda, Yumiko Yamazaki, Takumi Mukada, Weiguo Cheng, Masaru Chuba, Yozo Okazaki, Kazuki Saito, Akira Oikawa, Hayato Maruyama, Jun Wasaki, Tadao Wagatsuma, Keitaro Tawaraya   +11 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source