Use of LC-MS to characterize host cell protein removal during depth filtration. [PDF]
Biotechnol ProgAbstract The removal of host cell proteins (HCPs) is crucial in biopharmaceutical production, as residual impurities can impact product safety and efficacy. While a number of studies have demonstrated that depth filtration can provide significant HCP removal, there is little information on its effectiveness in removing specific HCPs.
Chu LK, Borujeni EE, Xu X, Zydney AL.
europepmc +2 more sources
NSE and ProGRP Are Promising Markers for Diagnosis, Efficacy Evaluation, Follow-Up Monitoring, and Prognosis of Small Cell Esophageal Carcinoma. [PDF]
Thorac CancerProGRP and NSE could distinguish SCEC from ESCC and EAC. ProGRP and NSE are associated with the clinical stage and prognosis of SCEC patients. ProGRP and NSE are effective indicators for evaluating therapeutic efficacy and disease recurrence in SCEC patients. ABSTRACT Background To investigate the clinical implications of serum carcinoembryonic antigen
Liu D, Wu D, Ni J, Zhang J, Xie S.
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Top-Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains. [PDF]
J Mass SpectromABSTRACT Aging significantly impacts brain function and increases susceptibility to neurodegenerative diseases, with notable sex dimorphism observed in aging‐related dementia, such as Alzheimer's disease. To better understand the molecular mechanisms of aging and dementia, it is essential to globally and accurately characterize biomolecules (e.g ...
Askarani MF +6 more
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Neuroendocrine differentiation as a survival prognostic factor in advanced non-small cell lung cancer [PDF]
Vojnosanitetski Pregled, 2007 Beckground/Aim. Neuroendrocine lung tumors are histologically heterogenous group of cancers with different clinical progression. In non-small cell lung cancer (NSCLC) neuroendocrine differentiation exists in 10-30% of patients.
Petrović Marina +2 more
doaj +1 more source
CO2-Induced Transcriptional Reorganization: Molecular Basis of Capnophillic Lactic Fermentation in Thermotoga neapolitana [PDF]
, 2020 Capnophilic lactic fermentation (CLF) is a novel anaplerotic pathway able to convert sugars to lactic acid (LA) and hydrogen using CO2 as carbon enhancer in the hyperthermophilic bacterium Thermotoga neapolitana.
Dipasquale, Laura +7 more
core +2 more sources
Proteomic analysis of differentially expressed proteins in Penaeus monodon hemocytes after Vibrio harveyi infection [PDF]
, 2010 BACKGROUND: Viral and bacterial diseases can cause mass mortalities in commercial shrimp aquaculture. In contrast to studies on the antiviral response, the responses of shrimps to bacterial infections by high throughput techniques have been reported only
Anchalee Tassanakajon +4 more
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Transcriptomic and Metabolomic Insights Into the Prebiotic Potential of Camellia Seed Oil for Enhancing Akkermansia muciniphila Proliferation In Vitro. [PDF]
Food Sci NutrCamellia seed oil is rich in bioactive compounds, which could promote the in vitro proliferation of Akkermansia muciniphila by reducing the oxidation–reduction potential of the media and activating the metabolism pathways involving energy and nucleic acid metabolism, protein synthesis, and environmental adaptation, thereby facilitating the nutrient ...
Chen X, Zhu Y, Mazhar M, Qin L.
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Proteomic approach to study the cytotoxicity of dioscin (saponin) [PDF]
, 2006 Dioscin, extracted from the root of Polygonatum zanlanscianense pamp, exhibits cytotoxicity towards human myeloblast leukemia HL-60 cells. Proteomic analysis revealed that the expression of mitochondrial associated proteins was substantially altered in ...
Che, CM +5 more
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ChemBioChem, Volume 24, Issue 21, November 2, 2023., 2023 Enzyme targets of activity‐based probes built on the anti‐neoplastic drug and antimicrobial agent carmofur in methicillin‐resistant Staphylococcus aureus (MRSA) have been identified. Chemoproteomic profiling revealed a broad reactivity of the probe against both cysteine and serine hydrolases, and identified uncharacterized bacterial enzymes; this has ...
Md Jalal Uddin +2 more
wiley +1 more source
Comparative Proteomic Analysis of Hymenolepis diminuta Cysticercoid and Adult Stages [PDF]
, 2018 Cestodiases are common parasitic diseases of animals and humans. As cestodes have complex lifecycles, hexacanth larvae, metacestodes (including cysticercoids), and adults produce proteins allowing them to establish invasion and to survive in the hostile ...
Bien, Justyna +6 more
core +2 more sources