Results 61 to 70 of about 43,490 (186)

Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein–protein interactions

Acta Crystallographica Section F Structural Biology Communications, 2015
P. falciparum orotate phosphoribosyltransferase, a potential target for antimalarial drugs and a conduit for prodrugs, crystallized as a structure with eight molecules per asymmetric unit that included some unique parasite-specific auto-inhibitory ...
Shiva Kumar, K. Krishnamoorthy, D. G. Mudeppa, P. Rathod   +3 more
semanticscholar   +1 more source

Allosteric Inhibition of Acinetobacter baumannii ATP Phosphoribosyltransferase by Protein:Dipeptide and Protein:Protein Interactions [PDF]

, 2021
Benjamin J. Read, Gemma Fisher, Oliver Wissett, Teresa F. G. Machado, John Nicholson, John B. O. Mitchell, Rafael G. da Silva   +6 more
openalex   +1 more source

Association between Cigarette Smoking and Hypoxanthine Guanine Phosphoribosyltransferase Activity

Kaohsiung Journal of Medical Sciences, 2005
The aim of this study was to investigate the association between smoking behavior and hypoxanthine guanine phosphoribosyltransferase (HGPRT) activity. A cross-sectional study was performed of 82 men, including 38 non-smokers and 44 smokers.
Shun-Jen Chang, Shiu-Min Chen, Shang-Lun Chiang, Kee-Lung Chang, Ying-Chin Ko   +4 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity*

Journal of Biological Chemistry, 2014
Background: Nicotinamide phosphoribosyltransferase (NAMPT) acts both as an enzyme in the production of the coenzyme NAD+ and as a secreted cytokine. Results: In breast cancer cells, NAMPT induces the epithelial-to-mesenchymal transition, a process that ...
D. Soncini, I. Caffa, G. Zoppoli, M. Cea, A. Cagnetta, M. Passalacqua, L. Mastracci, S. Boero, F. Montecucco, Giovanna Sociali, D. Lasiglié, P. Damonte, Alessia Grozio, Elena Mannino, A. Poggi, V. D’Agostino, F. Monacelli, Alessandro Provenzani, P. Odetti, A. Ballestrero, S. Bruzzone, A. Nencioni   +21 more
semanticscholar   +1 more source

Xanthine Phosphoribosyltransferase from Leishmania donovani [PDF]

, 1999
Armando Jardim, Susan E. Bergeson, Sarah Shih, Nicola Carter, Randall W. Lucas, Gilles Merlin, Peter J. Myler, Kenneth Stuart, Buddy Ullman   +8 more
openalex   +1 more source

Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator

, 2021
Mayuko Akiu, Takashi Tsuji, Kouki Iida, Yoshitaka Sogawa, Koji Terayama, Mika Yokoyama, Jun Tanaka, Daigo Asano, Tomohiro Honda, Ken Sakurai, Anthony B. Pinkerton, Tsuyoshi Nakamura   +11 more
openalex   +2 more sources

Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism*

Journal of Biological Chemistry, 2014
Background: Elevating NAD throughout the body improves oxidative metabolism in skeletal muscle and counteracts effects of high fat feeding. Results: Boosting NAD synthesis specifically in muscle does not recapitulate these effects.
David Frederick, James G. Davis, Antonio Davila, B. Agarwal, Shaday Michán, M. Puchowicz, Eiko Nakamaru-Ogiso, J. Baur   +7 more
semanticscholar   +1 more source

NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Blood Advances
: Elevated levels of the NAD+-generating enzyme nicotinamide phosphoribosyltransferase (NAMPT) are a common feature across numerous cancer types.
Debora Soncini, Pamela Becherini, Francesco Ladisa, Silvia Ravera, Adithya Chedere, Elisa Gelli, Giulia Giorgetti, Claudia Martinuzzi, Francesco Piacente, Luca Mastracci, Claudia Veneziano, Gianluca Santamaria, Fiammetta Monacelli, Moustafa S. Ghanem, Antonia Cagnetta, Fabio Guolo, Matteo Garibotto, Sara Aquino, Mario Passalaqua, Santina Bruzzone, Axel Bellotti, Michel A. Duchosal, Aimable Nahimana, Emanuele Angelucci, Chandra Nagasuma, Alessio Nencioni, Roberto Massimo Lemoli, Michele Cea   +27 more
doaj   +1 more source

Study on increase of nicotinamide mononucleotide yield by site-directed mutagenesis of nicotinamide phosphoribosyltransferase [PDF]

Zhongguo niangzao
Nicotinamide phosphoribosyltransferase (NAMPT) was a key rate-limiting enzyme in the biosynthetic pathway of nicotinamide mononucleotide (NMN). In this study, the NAMPT gene derived from Comamonadaceae bacterium was heterologous expressed in Escherichia ...
DONG Ping, XU Yifan, HOU Ying, LUO Xuegang, ZHANG Lin, QIAO Changsheng
doaj   +1 more source

Novel Mutations in Putative Nicotinic Acid Phosphoribosyltransferases of Mycobacterium tuberculosis and Their Effect on Protein Thermodynamic Properties [PDF]

, 2022
Yu‐Juan Zhang, Muhammad Tahir Khan, Madeeha Shahzad Lodhi, Hadba Al-Amrah, Salma Saleh Alrdahe, Hanan Ali Alatawi, Doaa Bahaa Eldin Darwish   +6 more
openalex   +1 more source