Zhongguo shiyan zhenduanxue, 2021 喹啉酸磷酸核糖转移酶(quinolinate phosphoribosyltransferase,QPRT)是色氨酸代谢过程中的关键酶,近年来,研究发现QPRT不仅参与诸多神经系统疾病的发病机制,还与感染性疾病、肿瘤的发生有关,本文就此进行综述。
张楠楠, 赵瑞鹏, 施建华
doaj
Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, Volume 16, Issue 1, Page 52-67, January 2026.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease [PDF]
, 2017 Alanna Watson +10 more
openalex +1 more source
Metal Nanoclusters for Cancer Imaging and Treatment
Advanced Functional Materials, Volume 36, Issue 2, 5 January 2026.This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu +5 more
wiley +1 more source
Allosteric Inhibition of Acinetobacter baumannii ATP Phosphoribosyltransferase by Protein:Dipeptide and Protein:Protein Interactions [PDF]
, 2021 Benjamin J. Read +6 more
openalex +1 more source
High‐Efficiency Genome Editing of Chlorella sp. by CRISPR/Cas9
Plant Biotechnology Journal, EarlyView.
Xinyu Cui +5 more
wiley +1 more source
Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Advanced Materials, Volume 38, Issue 1, 2 January 2026.The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar +7 more
wiley +1 more source
Mechanical Cues Regulate Cargo Sorting and Export at the Golgi
Advanced Science, Volume 13, Issue 1, 5 January 2026.A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino +21 more
wiley +1 more source
Study on increase of nicotinamide mononucleotide yield by site-directed mutagenesis of nicotinamide phosphoribosyltransferase [PDF]
Zhongguo niangzaoNicotinamide phosphoribosyltransferase (NAMPT) was a key rate-limiting enzyme in the biosynthetic pathway of nicotinamide mononucleotide (NMN). In this study, the NAMPT gene derived from Comamonadaceae bacterium was heterologous expressed in Escherichia ...
DONG Ping, XU Yifan, HOU Ying, LUO Xuegang, ZHANG Lin, QIAO Changsheng
doaj +1 more source