Results 271 to 280 of about 2,046,842 (395)

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

GSK3 phosphorylates and activates trehalose-6-phosphate synthase to improve trehalose production and thermotolerance in Ganoderma lucidum. [PDF]

Commun Biol
Wang L, Shi L, Wang H, Han Q, Hu Y, Zheng Q, Dong Z, Liu R, Zhao M, Chen H.   +9 more
europepmc   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

PKCγ-mediated Phosphorylation of Mtss1 Regulates the Dendritic Outgrowth and Spine Development of Cerebellar Purkinje Cells. [PDF]

Mol Neurobiol
Torrents-Solé P, Sziber Z, Shimobayashi E, Kapfhammer JP.   +3 more
europepmc   +1 more source

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

Cell, 2010
Edward L. Huttlin, Mark P. Jedrychowski, Joshua E. Elias, T. Goswami, R. Rad, S. Beausoleil, J. Villén, W. Haas, M. Sowa, S. Gygi   +9 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

New progress on the role and mechanism of tau protein in Alzheimer's disease and depression. [PDF]

Front Neurol
Wang Y, Zhou J, Zhou Q, Wang H.
europepmc   +1 more source

ATM-mediated co-chaperone DNAJB11 phosphorylation facilitates α-synuclein folding upon DNA double-stranded breaks [PDF]

Huan-Yun Chen, Chia-Yu Liao, Hsun Li, Yi‐Ci Ke, Chin‐Hsien Lin, S.–W. Teng   +5 more
openalex   +1 more source

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Cell, 1995
Zilong Wen, Z. Zhong, J. Darnell
semanticscholar   +1 more source

Advanced Cellulose‐Based Gels for Wearable Physiological Monitoring: From Fiber Modification to Application Optimization

Advanced Functional Materials, EarlyView.
This review discusses cellulose‐based hydrogels technology, analyzes their application progress in physiological signal monitoring, and explores the effects of pretreatment, crosslinking, and molding methods on gel performance, to provide valuable insights into the efficient utilization of plant fibers and the environmentally friendly development of ...
Zhiming Wang, Jinxuan Jiang, Kexin Wei, Xiaojian Zhou, Muhammad Wakil Shahzad, Yifan Li, Xuehua Zhang, Ben Bin Xu, Shengbo Ge   +8 more
wiley   +1 more source