Journal of Organic Chemistry, 2019 Fluorinated alcohols as solvents strongly influence and direct chemical reaction through donation of strong hydrogen bonds while being weak acceptors.
Štefan Možina, J. Iskra
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Application of computer-based methods to design inhibitors of zinc-dependent enzymes [PDF]
, 2018 Die vorliegende Arbeit veranschaulicht die Anwendung von Computergestütztes Wirkstoffdesign im Kontext der Entwicklung von Enzyminhibitoren. Sie berichtet, wie neuartige Hits für das antiparasitäre Target (SmHDAC8) mithilfe von virtuellem Screening ...
Melesina, Jelena
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Acetate Metabolism: The physiological role of ADP-forming acetyl-CoA synthetase and acetate kinase in Entamoeba histolytica [PDF]
, 2017 Entamoeba histolytica is a protozoan parasite that causes amoebic colitis and liver abscess in approximately 90 million people each year, resulting in 50,000-100,000 fatalities.
Dang, Thanh
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Structural basis for catalysis in a CDP-alcohol phosphotransferase
Nature Communications, 2014 The CDP-alcohol phosphotransferase (CDP-AP) family of integral membrane enzymes catalyses the transfer of a substituted phosphate group from a CDP-linked donor to an alcohol acceptor. This is an essential reaction for phospholipid biosynthesis across all
G. Sciara +12 more
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Two strictly polyphosphate-dependent gluco(manno)kinases from diazotrophic Cyanobacteria with potential to phosphorylate hexoses from polyphosphates [PDF]
, 2014 The single-copy genes encoding putative polyphosphate–glucose phosphotransferases (PPGK, EC 2.7.1.63) from two nitrogen-fixing Cyanobacteria, Nostoc sp. PCC7120 and Nostoc punctiforme PCC73102, were cloned and functionally characterized.
Albi Rodríguez, Tomás +1 more
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Repurposing Old Drugs: Substituted Benzodiazepines as New Antibacterial Agents [PDF]
, 2017 This project aims to develop a greater understanding of how old drugs can be repurposed into new and exciting therapeutic areas. In particular, developing an understanding of the antibacterial mode of action exerted by modified benzodiazepines possessing
MA, SHUWEN
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Crystallographic studies on membrane and cytoplasmic enzymes [PDF]
, 2013 Dissertation presented to obtain the Ph.D degree in Biochemistry, Structural BiochemistryHaloacid dehalogenase (HAD) superfamily (CL0137), includes a diverse range of enzymes that use an aspartate carboxylate as nucleophile (Aravind et al., 1998 ...
Nogly, Przemyslaw
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Characterization of a Phosphonate-Specific Cytidylyltransferase [PDF]
, 2016 Antibiotic resistance is a major global health concern that requires new therapeutic approaches. Furthermore, a lack of narrow spectrum antibiotics on the market produces unintended consequences with respect to changes in our microbial make up ...
Batul, Kissa
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DISCOVERY OF NOVEL MURAYMYCIN ANTIBIOTICS AND INSIGHT INTO THE BIOSYNTHETIC PATHWAY [PDF]
, 2018 New antibiotics with novel targets or mechanisms of action are needed to counter the steady emergence of bacterial pathogens that are resistant to antibiotics used in the clinic.
Cui, Zheng
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Acceptor Specificity Observed with Crude Preparation of Nucleoside Phosphotransferases
, 1973 A. Kamimura, K. Mitsugi, S. Okumura
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