Structure and mechanism of the RNA polymerase II CTD phosphatase Scp1 and large-scale preparation of the RNA polymerase II-TFIIF complex [PDF]
, 2006 TFIIF is the only general transcription factor that has been implicated in the preinitiation complex assembly, open complex formation, initiation and transcription elongation. In addition, TFIIF stimulates Fcp1, a central phosphatase needed for recycling
Kamenski, Tomislav
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Structural and functional characterization of the aminoacetone utilization microcompartment from Mycobacterium smegmatis MC2 155 [PDF]
, 2019 Bacterial microcompartments are proteinacious complexes made by bacteria, which metabolize volatile or cytotoxic chemicals, by sequestering a series of reactions within a selectively permeable shell.
Mallette, Evan
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Application of computer-based methods to design inhibitors of zinc-dependent enzymes [PDF]
, 2018 Die vorliegende Arbeit veranschaulicht die Anwendung von Computergestütztes Wirkstoffdesign im Kontext der Entwicklung von Enzyminhibitoren. Sie berichtet, wie neuartige Hits für das antiparasitäre Target (SmHDAC8) mithilfe von virtuellem Screening ...
Melesina, Jelena
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Acetate Metabolism: The physiological role of ADP-forming acetyl-CoA synthetase and acetate kinase in Entamoeba histolytica [PDF]
, 2017 Entamoeba histolytica is a protozoan parasite that causes amoebic colitis and liver abscess in approximately 90 million people each year, resulting in 50,000-100,000 fatalities.
Dang, Thanh
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Two strictly polyphosphate-dependent gluco(manno)kinases from diazotrophic Cyanobacteria with potential to phosphorylate hexoses from polyphosphates [PDF]
, 2014 The single-copy genes encoding putative polyphosphate–glucose phosphotransferases (PPGK, EC 2.7.1.63) from two nitrogen-fixing Cyanobacteria, Nostoc sp. PCC7120 and Nostoc punctiforme PCC73102, were cloned and functionally characterized.
Albi Rodríguez, Tomás +1 more
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Tobacco smoking and alcohol consumption as risk factors for thymoma - A European case-control study.
Cancer Epidemiology, 2019 PURPOSE Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. METHODS A European multi-
M. Eriksson +14 more
semanticscholar +1 more source
Repurposing Old Drugs: Substituted Benzodiazepines as New Antibacterial Agents [PDF]
, 2017 This project aims to develop a greater understanding of how old drugs can be repurposed into new and exciting therapeutic areas. In particular, developing an understanding of the antibacterial mode of action exerted by modified benzodiazepines possessing
MA, SHUWEN
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Lipid phosphatases and related proteins: from regulation of phospholipid metabolism to filopodia formation [PDF]
, 2007 Phospholipids and sphingolipids play critical roles in signal transduction, intracellular membrane trafficking, and control of cell growth and survival.
Sigal, Yury J.
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Acetate Metabolism in the Fungal Pathogen Cryptococcus Neoformans [PDF]
, 2023 Cryptococcus neoformans is an environmental basidiomycetous fungus with a worldwide distribution and a wide range of habitats. Inhalation of the desiccated yeasts or spores of C.
Ahmed, Oly
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Crystallographic studies on membrane and cytoplasmic enzymes [PDF]
, 2013 Dissertation presented to obtain the Ph.D degree in Biochemistry, Structural BiochemistryHaloacid dehalogenase (HAD) superfamily (CL0137), includes a diverse range of enzymes that use an aspartate carboxylate as nucleophile (Aravind et al., 1998 ...
Nogly, Przemyslaw
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