Results 161 to 170 of about 240,809 (322)

Multi‐Frame Image Registration for Automated Ventricular Function Assessment in Single Breath‐Hold Cine MRI Using Limited Labels

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose This study aims to develop an automated framework for operator‐independent assessment of cardiac ventricular function from highly accelerated images. Methods We introduce a deep learning framework that generates reliable ventricular volumetric parameters and strain measures from fully sampled and retrospectively accelerated MR images ...
Aya Ghoul   +7 more
wiley   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper   +6 more
wiley   +1 more source

Leveraging Part‐Based NeRF for Robot Self‐Modeling and Control

open access: yesSmartBot, EarlyView.
A robot stands in front of a camera, striking a variety of distinct poses to provide diverse visual data. The camera then captures these images in sequence, storing every detail of the robot’s body position and movements. Using this visual input, the robot can gradually process and analyze the information, ultimately developing a basic sense of self ...
Kejun Hu   +3 more
wiley   +1 more source

CCD Photometric Observations and Light Curve Synthesis of the Near-Contact Binary XZ Canis Minoris

open access: gold, 2009
Chun‐Hwey Kim   +4 more
openalex   +1 more source

Stress‐Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton‐Dependent Mechanisms

open access: yesSmall, EarlyView.
Proteotoxic stress induced by alpha‐synuclein aggregates drives rapid, cytoskeleton‐dependent re‐localization of mammalian proteasomes and formation of transient aggregate‐associated droplets (TAADs). Single‐molecule localization microscopy, light‐sheet imaging, nanopipette injection, single‐cell patch clamp, and single‐particle tracking reveal a ...
Michael J Morten   +15 more
wiley   +1 more source

Macropinocytic Uptake and pH‐Responsive Endolysosomal Processing Drive Sustained Chemotherapeutic Efficacy of High‐Load Core@Shell Nanocarriers in Colorectal Cancer

open access: yesSmall Science, EarlyView.
This study develops core@shell nanocarriers with an exceptionally high chemotherapy drug payload, exhibiting strong cytotoxic effects. Using this adaptable nanocarrier‐synthesis platform, herein, the cellular uptake pathway and intracellular journey of the nanocarriers are elucidated with different probe‐based imaging strategies.
Dolma Choezom   +11 more
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters   +6 more
wiley   +1 more source

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