Results 161 to 170 of about 316,881 (368)

Development of an efficient mice model of cancer‐associated cardiac cachexia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong   +9 more
wiley   +1 more source

Steps toward a classifier for the Virtual Observatory. I. Classifying the SDSS photometric archive

open access: yes, 2007
Modern photometric multiband digital surveys produce large amounts of data that, in order to be effectively exploited, need automatic tools capable to extract from photometric data an objective classification. We present here a new method for classifying
D'Abrusco, R.   +4 more
core  

From Oxygen to Tellurium: The Impact of the Chalcogen on Nucleophilicities and Basicities of Isochalcogenourea Catalysts

open access: yesAngewandte Chemie International Edition, EarlyView.
Incorporation of different chalcogen atoms allows for the fine‐tuning of nucleophilicity and basicity of commonly used isochalcogenourea organocatalyst scaffolds. Kinetic and thermodynamic descriptors for the molecular properties of the catalysts are introduced as tools to predict their efficiency and tested in acyl transfer and allenoate activation ...
Lotte Stockhammer   +8 more
wiley   +1 more source

Early synapsids neurosensory diversity revealed by CT and synchrotron scanning

open access: yesThe Anatomical Record, EarlyView.
Abstract Non‐mammaliaform synapsids (NMS) represent the closest relatives of today's mammals among the early amniotes. Exploring their brain and nervous system is key to understanding how mammals evolved. Here, using CT and Synchrotron scanning, we document for the first time three extreme cases of neurosensory and behavioral adaptations that probe ...
J. Benoit   +6 more
wiley   +1 more source

JWST Imaging of the Closest Globular Clusters—VI. The Lowest‐Mass Objects in M 4 and the Galactic Bulge

open access: yesAstronomische Nachrichten, EarlyView.
ABSTRACT We present James Webb Space Telescope observations of M 4—the closest globular cluster—that probe the lower Main Sequence down to the hydrogen‐burning limit. The unveiled stellar sequence reaches much fainter luminosities than previously possible, revealing a few extremely red objects that are consistent with brown dwarfs as cool as Teff∼1000K$
L. R. Bedin   +10 more
wiley   +1 more source

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala   +4 more
wiley   +1 more source

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