Results 271 to 280 of about 146,804 (365)

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

open access: yesThe FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara   +9 more
wiley   +1 more source

A binary system in the S cluster close to the supermassive black hole Sagittarius A. [PDF]

open access: yesNat Commun
Peißker F   +6 more
europepmc   +1 more source

A Personalized 4D Workflow for the Manufacturing of Functional and Removable Esthetic Devices: A Technical Report

open access: yesJournal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective This technical report describes a fully digital workflow for the manufacturing of a functional removable esthetic device (FRED) that addresses multiple clinical scenarios before prosthetic rehabilitation. The proposed method integrates advanced digital tools to achieve functional and esthetic outcomes while ensuring reversibility and
Mauro Merli   +6 more
wiley   +1 more source

A comparison of super‐resolution microscopy techniques for imaging tightly packed microcolonies of an obligate intracellular bacterium

open access: yesJournal of Microscopy, EarlyView.
Abstract Conventional optical microscopy imaging of obligate intracellular bacteria is hampered by the small size of bacterial cells, tight clustering exhibited by some bacterial species and challenges relating to labelling such as background from host cells, a lack of validated reagents, and a lack of tools for genetic manipulation.
Alison J. North   +7 more
wiley   +1 more source

Single‐cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Responses to external and internal dangers is essential for survival and homeostatic regulation. Hypothalamic corticotropin‐releasing hormone neurons (CRHNs) play a pivotal role in regulating neuroendocrine responses to fear and stress.
Naresh K. Hanchate
wiley   +1 more source

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