Results 271 to 280 of about 316,881 (368)

New biosensors and transgenic mice for multiplex cGMP imaging

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters   +6 more
wiley   +1 more source

Photometric measurements of lighting quality: An overview

open access: yesBuilding and Environment, 2018
T. Kruisselbrink, R. Dangol, A. Rosemann
semanticscholar   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig   +7 more
wiley   +1 more source

Spectroscopic Supermassive Dark Star candidates. [PDF]

open access: yesProc Natl Acad Sci U S A
Ilie C, Mahmud SS, Paulin J, Freese K.
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Disentangling mechanisms that mediate soil fungal α and β diversity during forest secondary succession

open access: yesEcography, EarlyView.
Understanding the mechanisms controlling community diversity is a central, topic in ecology, particularly in microbial ecology. Although species pools and local assembly processes are believed to play non‐negligible roles in shaping the within‐community (α) and among‐community (β) diversity of microbial communities, their relative importance as ...
Xiao Zhang   +10 more
wiley   +1 more source

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