Results 301 to 310 of about 146,804 (365)

Control of action potential afterdepolarizations in the inferior olive by inactivating A‐type currents through KV4 channels

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend KV4 channel availability regulates inferior olive action potential duration. The durations of action potentials in inferior olive neurons (blue) depend strongly on preceding membrane potential, with afterdepolarizations varying over the physiological range by almost two orders of magnitude (open circles). Voltage clamp recordings
Ziyad W. Sultan   +2 more
wiley   +1 more source

Chromatography in Downstream Processing of Recombinant Adeno‐Associated Viruses: A Review of Current and Future Practises

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 5, Page 1067-1086, May 2025.
ABSTRACT Recombinant adeno‐associated virus (rAAV) has emerged as an attractive gene delivery vector platform to treat both rare and pervasive diseases. With more and more rAAV‐based therapies entering late‐stage clinical trials and commercialization, there is an increasing pressure on the rAAV manufacturing process to accelerate drug development ...
Julius Klemens Lorek   +2 more
wiley   +1 more source

Miniature chicken ileal explant culture to investigate the inflammatory response induced by pathogen-associated molecular patterns. [PDF]

open access: yesFront Vet Sci
Mátis G   +9 more
europepmc   +1 more source

Machine Learning‐Powered Optimization of a CHO Cell Cultivation Process

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 5, Page 1153-1164, May 2025.
This study investigated the use of a machine learning algorithm to optimize the cultivation of CHO cells used to produce therapeutic monoclonal antibodies. Richter and coworkers developed an artificial neural network that was trained on a very diverse dataset of historical and new cultivation data to find better cultivation conditions. After validation
Jannik Richter   +7 more
wiley   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

open access: yesGlia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla   +7 more
wiley   +1 more source

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