Results 221 to 230 of about 10,528 (298)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Relaxor-like ferroelectric response and achiral-chiral switching in an amorphous molecular solid. [PDF]

Nat Commun
Liu H, Xiong Y, Xie T, Gong C, Ren S.
europepmc   +1 more source

Hydrogen‐bond‐mediated retention of a phenolic SNAP analogue in polyvinyl alcohol/PEG hydrogels for sustained nitric oxide release and antibacterial activity

Smart Molecules, EarlyView.
A hydrogen‐bond‐donating NO donor was designed to interact specifically with the hydrogel network, thereby minimizing donor leakage and achieving prolonged NO release. Abstract Nitric oxide (NO)‐releasing materials have attracted considerable interest for their potential in diverse biomedical applications.
Yixin Zhu, Peixuan Wu, Shuting Zhang, Congjun Xu, Guanghua Xia, Jiangli Fan, Nicola E. Brasch, Yang Zhou, Yuanyuan Liu   +8 more
wiley   +1 more source

Dihydrobenzofuro[3,2-<i>b</i>]benzofuran: a light-driven molecular switch with fluorescence switching, bistability, and intrinsic chirality. [PDF]

Chem Sci
Hassan F, Velmurugan N, Tan J, Yi YQ, Torubaev Y, Chormaic SN, Narita A, Luscombe C.   +7 more
europepmc   +1 more source

Scalable Room‐Temperature Terahertz Graphene Cameras

Small Methods, EarlyView.
ABSTRACT Terahertz (THz) imaging has emerged as a powerful tool for non‐destructive, label‐free analysis across several scientific disciplines, ranging from materials science to biomedical research. By capturing the spatial‐dependent information in a broad range of frequencies, this technique enables the identification of chemical composition ...
Lili Shi, Leonardo Viti, Miriam S. Vitiello   +2 more
wiley   +1 more source

Valence- and Phase-Engineered VP/WOx Heterojunction Microneedles for Photoresponsive Therapy of Infected Wounds. [PDF]

Small
Dong Y, Zhou Y, Han Z, Zhang Z, Huang C, Chen T, Chen Y, Wang S.   +7 more
europepmc   +1 more source

Optical Control of Therapeutic Synthetic Cells: Controlling Biomolecule Synthesis, Activation, and Communication

Small Methods, EarlyView.
Combining synthetic cells engineering, cell‐free expression, and optical regulation may enable a new generation of programmable synthetic cell platforms. By providing spatiotemporal control over biomolecule synthesis, activation, transport, release, and communication, light offers a versatile strategy for coordinating proteins, RNAs, peptides, and ...
Gia Bao Leon Hoang, Taniya Chakraborty
wiley   +1 more source

Recent Progresses in Photoresponsive π‑Conjugated Organogelators for Biomaterial Applications: Challenges and Future Perspectives. [PDF]

Precis Chem
Rajasekar M, Meenambigai S.
europepmc   +1 more source

Understanding the Dynamics of Mechanically Interlocked Molecular Systems via Metadynamics Simulations

The Chemical Record, EarlyView.
This Personal Account discusses how molecular simulations help uncover motion, shuttling mechanisms, and kinetics in mechanically interlocked molecules such as rotaxanes and catenanes. Mechanically interlocked molecules, such as rotaxanes and catenanes, display complex internal dynamics and reciprocal motions that are central to their use as artificial
Clara Sabrià, Luigi Leanza, Massimo Delle Piane, Max von Delius, Ferran Feixas, Xavi Ribas, Giovanni M. Pavan   +6 more
wiley   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source