Results 51 to 60 of about 20,257 (257)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Suspension Photopolymerization of Methyl Methacrylate and ATRP Grafting of Thermo‐Responsive Polymers Using a Perylediimide Derivative Photoinitiator

Macromolecular Materials and Engineering
The first aim of this study is to develop a photo‐ATRP process using methyl methacrylate (MMA) by employing a novel perylenediimide derivative (PDI) as photoinitiator.
Aurel Diacon, Florica Rizea, Alexandra Mocanu, Adrian Dinescu, Cristina Stavarache, Luiza Izabela Jinga, Cristian N. Mihăilescu, Edina Rusen   +7 more
doaj   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Obtention and Characterization of TiO₂-Folic Acid-ZnPc Semiconductor Nanoparticles for Photodynamic Therapy Against Glioma Cells

Pharmaceutics
Background/Objectives: This study reports the synthesis of TiO2 nanoparticles, their functionalization with folic acid (FA), and the subsequent loading with zinc phthalocyanine (ZnPc) to develop photosensitizers for photodynamic therapy (PDT) targeting ...
Citlali Ekaterina Rodríguez-Pérez, Sonia Rodríguez-García, Ma. Elena Manríquez-Ramírez, A. Martin Ortiz-Torres, Francisco Tzompantzi-Morales, Emma Ortiz-Islas   +5 more
doaj   +1 more source

Application and design of esterase-responsive nanoparticles for cancer therapy

Drug Delivery, 2019
Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects.
Haonan Dong, Long Pang, Hailin Cong, Youqing Shen, Bing Yu   +4 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Antimicrobial Photodynamic Therapy: Novel Concept for Foodborne Pathogens

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
Changes in agricultural practices, individual diversity, the considerable size of the global food trade, immigrant and tourist circulation, with microorganism transformations have led to the formation of microorganisms that are resistant to chemicals and
Gökçe Gürün, Funda Karbancıoğlu Güler   +1 more
doaj   +1 more source

Pediatric photosensitivity [PDF]

Photodermatology, Photoimmunology & Photomedicine, 2012
SummaryPhotosensitivity is a rarely encountered problem in the pediatric population. It may be caused by a diverse group of primary, idiopathic photosensitivity conditions, or may reflect photoexacerbation of an existing dermatosis. In addition, there are several genodermatoses, metabolic disorders, and connective tissue disorders that can present with
openaire   +2 more sources

Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes

Advanced Science, EarlyView.
A one‐step, asymmetric reductive coupling of alkynes and oxa‐ and aza‐bicyclic olefins using a cobalt/photoredox catalytic system through desymmetrization. ABSTRACT Bicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules.
Subhankar Pradhan, Arko Saha, Bholanath Maity, Sayan Dutta, Luigi Cavallo, Basker Sundararaju   +5 more
wiley   +1 more source

Advances in the Design of Polysaccharide-based Food Packaging Materials and Their Application for Photodynamic Antimicrobial Activity

Shipin gongye ke-ji
Food packaging is an important area of food research, and it plays an important role in maintaining food quality. Food is very easy to be contaminated by microorganisms during storage and transportation, resulting in spoilage of food, which can lead to ...
Yueyue LIU, Qianqian CHEN, Fang XIE, Zhijun HE, Jiaojiao ZHOU, Jie CAI   +5 more
doaj   +1 more source