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Activatable Phototheranostic Materials for Imaging-Guided Cancer Therapy
ACS Applied Materials & Interfaces, 2019Cancer theranostics, which combines diagnostic and therapeutic effects into one entity, holds promise in precision medicine. Conventional theranostic agents possess always-on imaging signals and cytotoxic effects and thus often encounter poor selectivity or specificity in cancer treatment.
Penghui Cheng, Kanyi Pu
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NIR‐II AIEgens for Infectious Diseases Phototheranostics
Angewandte ChemieAbstractPathogenic infectious diseases have persistently posed significant threats to public health. Phototheranostics, which combines the functions of diagnostic imaging and therapy, presents an extremely promising solution to block the spread of pathogens as well as the outbreak of epidemics owing to its merits of a wide‐spectrum of activity, high ...
Dingyuan Yan +4 more
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Indocyanine Green Conjugated Phototheranostic Nanoparticle for Photobiomodulation
SSRN Electronic Journal, 2020Phototheranostics represents a highly promising paradigm for cancer therapy, although selecting an appropriate optical imager for clinical use remains challenging. We evaluated the phototheranostic nanoparticle-related properties of liposomally formulated phospholipid-conjugated indocyanine green, denoted as LP-iDOPE, for cancer diagnosis and treatment
Kenta Shinoda +17 more
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Design of superior phototheranostic agents guided by Jablonski diagrams
Chemical Society Reviews, 2020This review summarizes how Jablonski diagrams guide the design of advanced organic optical agents and improvement of disease phototheranostic efficacies.
Guangxue Feng, Guo-Qiang Zhang, Dan Ding
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Applications of phototheranostic nanoagents in photodynamic therapy
Nano Research, 2014Nanotherapeutics has an increasing role in the treatment of diseases such as cancer. In photodynamic therapy (PDT) a therapeutically inactive photosensitizer compound is selectively activated by light to produce molecules capable of killing diseased cells and pathogens.
Jayeeta Bhaumik +4 more
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Organic photosensitizers: from molecular design to phototheranostics
Chemical Society ReviewsPhotodynamic therapy (PDT) has emerged as a highly promising approach for tumor treatment, this review discusses molecular engineering strategies through rational structure design, focusing on five critical aspects.
Tian Zhang +3 more
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Mechanistic Insights Into NIR‐II AIEgens Boosted Multimodal Phototheranostics
SmallAbstractExploiting single molecular species synchronously affording powerful second near‐infrared (NIR‐II) fluorescence, superior photoacoustic output, prominent reactive oxygen species generation, and satisfactory photothermal conversion is supremely appealing for phototheranostics, yet remains formidably challenging.
Jun Zhu +4 more
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pH-Activatable NIR Hemicyanine for Mitochondria-Targeted Cancer Phototheranostics
Analytical ChemistryPhotodynamic therapy (PDT) has garnered significant attention for cancer treatment due to its noninvasive nature, reduced drug resistance, and spatiotemporal controllability. However, traditional photosensitizers (PSs) face limitations such as severe systemic phototoxicity and shallow tissue penetration, which hinder the widespread clinical application
Yurong Liu +7 more
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