Results 131 to 140 of about 12,719 (310)

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

open access: yesAdvanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi   +12 more
wiley   +1 more source

Femtosecond laser ultrafast photothermal exsolution

open access: yesInternational Journal of Extreme Manufacturing
Exsolution, as an effective approach to constructing particle-decorated interfaces, is still challenging to yield interfacial films rather than isolated particles.
Lurun Xu   +4 more
doaj   +1 more source

Self-enriching nanozyme with photothermal-cascade amplification for tumor microenvironment-responsive synergistic therapy and enhanced photoacoustic imaging

open access: yesMaterials Today Bio
Achieving precise intratumoral accumulation and coordinated activation remains a major challenge in nanomedicine. Photothermal therapy (PTT) provides spatiotemporal control, yet its efficacy is hindered by heterogeneous distribution of PTT agents and ...
Xi Zhu   +7 more
doaj   +1 more source

Robust and Thermally Stable Silicone Aerogels with Hyperconnected Network via Kinetically Optimized Hyperbranched Silane Precursors

open access: yesAdvanced Science, EarlyView.
Reactivity‐Programmed Assembly: A kinetic‐control strategy is reported for constructing hyperconnected silicone aerogels with a robust “thick‐neck” architecture. By exploiting the reactivity disparity of precursors, flexible segments are uniformly embedded within a rigid skeleton.
Aoqing Yan   +9 more
wiley   +1 more source

Glutamate nanoregulator for metabolic immunotherapy of biofilm-associated implant infections

open access: yesJournal of Nanobiotechnology
Background Implant-associated infections caused by Staphylococcus aureus biofilms remain difficult to eradicate because the extracellular matrix and metabolic heterogeneity jointly suppress antibiotic penetration and immune clearance.
Heng Wu   +9 more
doaj   +1 more source

LSPR-driven interfacial synergy in an Au@Prussian blue heterostructures for potent chemo-photothermal therapy

open access: yesMaterials & Design
Nanozyme-based tumor therapies are hampered by the low catalytic efficiency and limited stability of monometallic nanonzymes, as well as insufficient H2O2 in the tumor microenvironment.
Mengting Pan   +9 more
doaj   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

open access: yesAdvanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao   +6 more
wiley   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

open access: yesAngewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo   +3 more
wiley   +2 more sources

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