Results 101 to 110 of about 1,477,998 (362)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Ancestral Protein‐Based Lighting

Advanced Materials, EarlyView.
The ancestral sequence reconstruction (ASR) method applied to a large dataset of modern fluorescent proteins (FPs) led to a bright ancestral‐like FP suitable for photon down‐conversion in bio‐hybrid light‐emitting diodes (Bio‐HLEDs). Abstract Protein‐optoelectronics is a paradigm toward eco‐designed and sustainable technologies.
Stephanie Willeit, Alexander Mauz, David Gutiérrez‐Armayor, Joseph Arbash, Jesús Agustín Banda‐Vázquez, Sergio Martí, Pedro B. Coto, Rubén D. Costa   +7 more
wiley   +1 more source

Unrealistic phylogenetic trees may improve phylogenetic footprinting [PDF]

Bioinformatics, 2017
Abstract Motivation The computational investigation of DNA binding motifs from binding sites is one of the classic tasks in bioinformatics and a prerequisite for understanding gene regulation as a whole.
Nettling, Martin, Treutler, Hendrik, Cerquides, Jesús, Grosse, Ivo   +3 more
openaire   +4 more sources

UTact: Underwater Vision‐Based Tactile Sensor with Geometry Reconstruction and Contact Force Estimation

Advanced Robotics Research, EarlyView.
Embedded flexible sensing technologies advance underwater soft robotics, yet most systems still suffer from hysteresis and limited perceptiveness. Instead, vision‐based tactile sensors provide reliable and rapid feedback essential for complex underwater tasks.
Qiyi Zhang, Zonghao Zuo, Haoxuan Wang, Bin Liu, Yilidusi Yilihamu, Li Wen   +5 more
wiley   +1 more source

Ultrafast Approximation for Phylogenetic Bootstrap

Molecular biology and evolution, 2013
Nonparametric bootstrap has been a widely used tool in phylogenetic analysis to assess the clade support of phylogenetic trees. However, with the rapidly growing amount of data, this task remains a computational bottleneck.
B. Minh, Minh Anh Nguyen, A. von Haeseler   +2 more
semanticscholar   +1 more source

Phylogenetic Networks

, 2020
Phylogenetics is the study of the evolutionary relationships between organisms. One of the main challenges in the field is to take biological data for a group of organisms and to infer an evolutionary tree, a graph that represents these relationships.
Gross, Elizabeth, Long, Colby, Rusinko, Joseph   +2 more
openaire   +2 more sources

Insect‐Microbe‐Based Laccase: Untapped Natural Resource for Industrial and Biotechnological Applications

Advanced Sustainable Systems, EarlyView.
The insect‐microbe interplay fulfills a key ecological role involving the degradation of ligninocellulose biomass. This is coordinated by the secretion of different kinds of proteins, of which ligninolytic enzymes, such as laccases (Lacs), are of prime importance.
Michael Dare Asemoloye, Adeyinka Michael Gbadebo, Tunde Sheriffdeen Bello, Olumayowa Mary Olowe, Akinlolu Olalekan Akanmu, Marta Elisabetta Eleonora Temporiti, Adeyinka Odebode, Segun Oladiran Babarinde, Tsigereda Weldemichael, Leonard Chitongo, Solveig Tosi, Mario Andrea Marchisio   +11 more
wiley   +1 more source

The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes

BMC Bioinformatics, 2008
BackgroundRandom community genomes (metagenomes) are now commonly used to study microbes in different environments. Over the past few years, the major challenge associated with metagenomics shifted from generating to analyzing sequences. High-throughput,
Folker Meyer, Daniel Paarmann, Mark D'Souza, Robert Olson, Elizabeth M. Glass, Michael Kubal, Tobias Paczian, Alexis A. Rodriguez, Rick L. Stevens, Andreas Wilke, Jared Wilkening, Robert A. Edwards   +11 more
semanticscholar   +1 more source

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non‐heading Chinese Cabbage

Advanced Science, EarlyView.
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren   +10 more
wiley   +1 more source