Results 151 to 160 of about 1,161,913 (308)
A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation
Advanced Science, EarlyView.The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka +10 morewiley +1 more sourceStructure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals
Advanced Science, EarlyView.A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang +11 morewiley +1 more sourceMechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways
Advanced Science, EarlyView.The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang +20 morewiley +1 more sourceEpidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation
Advanced Science, EarlyView.The lamina joint determines leaf angle and plant architecture. Xu et al. establish a live‐imaging system for the rice lamina joint and reveal that asymmetric epidermal cell elongation and division between the lateral and medial edges drive leaf angle formation.Yiru Xu, Heng Zhou, Xiaojiang Wu, Wuyu Cui, Shouling Xu, Xi He, Dan Xiang, Ming Zhou, Xiuqin Rao, Lilan Hong +9 morewiley +1 more sourceCsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis
Advanced Science, EarlyView.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin +14 morewiley +1 more sourcePhylogenetics
Scholarpedia, 2008 J. Howard Frank, J. Howard Frank, Michael C. Thomas, Allan A. Yousten, F. William Howard, Robin M. Giblin-davis, John B. Heppner, Robert L. Zuparko, Norma E. Sánchez, María G. Luna, Marta Goula, John B. Heppner, Andrey N. Alekseev, Rosalind R. James, John L. Capinera, Phyllis G. Weintraub, David Horton, J. Howard Frank, Kenneth W. Mccravy, David G. Riley, David C. Marshall, Cyrus Abivardi, Marjorie A. Hoy, Efat M. Abou-fakhr hammad, Jason G. Froeba, David Legg, Heather J. Mc Auslane, Qiao Wang, Cyrus Abivardi, Seth Bybee, Menachem J. Berlinger, Sarah Lebiush-mordechi, Harold A. Denmark, J. Howard Frank, Whitney Cranshaw, John L. Capinera, John B. Heppner, Chris Asaro, Erik Christiansen, William J. Roltsch, Dale E. Meyerdirk, Lewis B. Coons, Marjorie Rothschild, Minos E. Tzanakakis, Pauline O. Lawrence, Alfred G. Wheeler, Thomas J. Henry, Russell F. Mizell, Partricia A. Mizell, John B. Heppner, Lois B. O’ brien, Menachem J. Berlinger, Anthony Rossi, Wayne B. Hunter, Charles Vincent, Gérald Chouinard, Tracy Leskey, Deborah L. Matthews, Peter G. Kevan, Antonio Felicioli, Mauro Pinzauti, Olle Pellmyr, John T. Trumble, Danel B. Vickerman, Cyrus Abivardi, Robert McSorley, K. K. Verma, John L. Capinera, Peter H. Adler, Igor Uspensky, Donald W. Hall, John L. Capinera, Juan M. Alvarez, John L. Capinera, Eugene J. Gerberg, Lawrence E. Hurd, Lawrence E. Hurd, Patrick De Clercq, John B. Heppner, J. Howard Frank, Lawrence I. Gilbert, Robert Rybczynski, Christopher Tipping, James H. Tsai, Philip Weinstein, David Slaney, Peter H. Adler, Zeyaur R. Khan, John A. Pickett, John B. Heppner, Cyrus Abivardi, Katie Goodman, Kenneth W. McCravy, Andrei Sourakov +93 more +4 more sources
