Results 211 to 220 of about 850,464 (362)

Bounding the softwired parsimony score of a phylogenetic network [PDF]

open access: yesarXiv
In comparison to phylogenetic trees, phylogenetic networks are more suitable to represent complex evolutionary histories of species whose past includes reticulation such as hybridisation or lateral gene transfer. However, the reconstruction of phylogenetic networks remains challenging and computationally expensive due to their intricate structural ...
arxiv  

Identification of an Activity Selector for the Nitroso‐Forming Activity in Bacterial Type‐III Copper Enzymes

open access: yesAngewandte Chemie International Edition, Accepted Article.
O‐aminophenol oxidases, a specialized subclass of type‐III copper proteins, play a crucial role in the biosynthesis of bioactive nitrosophenols which display antiretroviral and blood cholesterol lowering activity. Another related subclass of type‐III copper proteins, tyrosinases, closely resemble o‐aminophenol oxidases both structurally and ...
Hoa Le Xuan, Felix Panis, Annette Rompel
wiley   +1 more source

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

open access: yesAngewandte Chemie International Edition, Accepted Article.
Modular megasynthases, such as polyketide synthases (PKSs) and non‐ribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically and ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering.
Martin Baunach   +6 more
wiley   +1 more source

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

open access: yesAngewandte Chemie International Edition, Accepted Article.
Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologically active natural products. P.
Shuaibing Zhang   +7 more
wiley   +1 more source

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