Results 11 to 20 of about 330 (99)

Identifying promising sequences for protein engineering using a deep transformer protein language model

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1471-1486, November 2023., 2023
Abstract Protein engineers aim to discover and design novel sequences with targeted, desirable properties. Given the near limitless size of the protein sequence landscape, it is no surprise that these desirable sequences are often a relative rarity. This makes identifying such sequences a costly and time‐consuming endeavor. In this work, we show how to
Trevor S. Frisby   +1 more
wiley   +1 more source

On the role of metaheuristic optimization in bioinformatics

open access: yesInternational Transactions in Operational Research, Volume 30, Issue 6, Page 2909-2944, November 2023., 2023
Abstract Metaheuristic algorithms are employed to solve complex and large‐scale optimization problems in many different fields, from transportation and smart cities to finance. This paper discusses how metaheuristic algorithms are being applied to solve different optimization problems in the area of bioinformatics. While the text provides references to
Laura Calvet   +3 more
wiley   +1 more source

Selection on standing genetic variation mediates convergent evolution in extremophile fish

open access: yesMolecular Ecology, Volume 32, Issue 18, Page 5042-5054, September 2023., 2023
Abstract Hydrogen sulfide is a toxic gas that disrupts numerous biological processes, including energy production in the mitochondria, yet fish in the Poecilia mexicana species complex have independently evolved sulfide tolerance several times. Despite clear evidence for convergence at the phenotypic level in these fishes, it is unclear if the repeated
Kara Ryan   +5 more
wiley   +1 more source

Pitfalls of using sequence databases for heterologous expression studies – a technical review

open access: yesThe Journal of Physiology, Volume 601, Issue 9, Page 1611-1623, 1 May 2023., 2023
Abstract figure legend Projects involving heterologous gene expression are often characterised by similar steps. Initially, database research (A) is necessary to retrieve information of full or partial sequences of a gene of interest. A multitude of genome assemblies are annotated and deposited in public databases or are available for refined search ...
Stephan Maxeiner   +2 more
wiley   +1 more source

Fluctuating ecological networks: A synthesis of maximum‐entropy approaches for pattern detection and process inference

open access: yesMethods in Ecology and Evolution, Volume 13, Issue 11, Page 2306-2317, November 2022., 2022
Abstract Ecological networks such as plant–pollinator systems and food webs vary in space and time. This variability includes fluctuations in global properties such as the total number and intensity of interactions in the network but also in the number and intensity of local (i.e. node level) species interactions.
Tancredi Caruso   +3 more
wiley   +1 more source

A branching process approach to level‐k phylogenetic networks

open access: yesRandom Structures &Algorithms, Volume 61, Issue 2, Page 397-421, September 2022., 2022
Abstract The mathematical analysis of random phylogenetic networks via analytic and algorithmic methods has received increasing attention in the past years. In the present work we introduce branching process methods to their study. This approach appears to be new in this context.
Benedikt Stufler
wiley   +1 more source

Ancestral sequence reconstruction of the CYP711 family reveals functional divergence in strigolactone biosynthetic enzymes associated with gene duplication events in monocot grasses

open access: yesNew Phytologist, Volume 235, Issue 5, Page 1900-1912, September 2022., 2022
Summary The strigolactone (SL) class of phytohormones shows broad chemical diversity, the functional importance of which remains to be fully elucidated, along with the enzymes responsible for the diversification of the SL structure. Here we explore the functional evolution of the highly conserved CYP711A P450 family, members of which catalyze several ...
Marcos H. Vinde   +10 more
wiley   +1 more source

Enchrony

open access: yesWIREs Cognitive Science, Volume 13, Issue 4, July/August 2022., 2022
The to‐and‐fro of social interaction—termed enchrony—has been understudied in the language sciences, but new developments are changing how we think about the relation between language and mind. Abstract What are the properties of mind that make language the way it is, and languages the way they are? To answer those questions, it is necessary to look at
N. J. Enfield
wiley   +1 more source

Widespread co‐occurrence of Sebacinales and arbuscular mycorrhizal fungi in switchgrass roots and soils has limited dependence on soil carbon or nutrients

open access: yesPLANTS, PEOPLE, PLANET, Volume 3, Issue 5, Page 614-626, September 2021., 2021
This work addresses a novel group of Sebacinales mycorrhizal fungi being considered for development as inoculants in managed ecosystems because of their potential access to nutrients in soil organic matter. By comparing the diversity, distributions, and abundances of the Sebacinales with the more common arbuscular mycorrhizal fungi in switchgrass, a ...
Marissa R. Lee, Christine V. Hawkes
wiley   +1 more source

An ecological driver for the macroevolution of morphological polymorphism within colonial invertebrates

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 336, Issue 3, Page 231-238, April 2021., 2021
When colonies first evolve from solitary ancestors, the life‐history strategy of the colony remains constrained by the life‐history strategies of the individual modules within the colony until a new polymorph type evolves. Colonies can evolve further strategies by regulating the frequencies of body types within the colony.
Carl Simpson
wiley   +1 more source

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