Results 31 to 40 of about 453,178 (226)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

The use of phylogeny to interpret cross-cultural patterns in plant use and guide medicinal plant discovery: an example from Pterocarpus (Leguminosae) [PDF]

, 2011
The study of traditional knowledge of medicinal plants has led to discoveries that have helped combat diseases and improve healthcare. However, the development of quantitative measures that can assist our quest for new medicinal plants has not greatly ...
A Ankli, A Chakraborty, A Jain, A Kar, A Prinzing, A Purvis, A Rambaut, A Stamatakis, A Valentin, AJ Paton, AK Nadkarni, AN Muellner, AP de Candolle, B Bennett, B Kameswara Rao, BB Klitgaard, BB Klitgaard, BC Bennett, Bente B. Klitgaard, BR Baum, C Clarkson, C Lans, C Saslis-Lagoudakis, C. Haris Saslis-Lagoudakis, CD Specht, CD Specht, CE Hughes, CH Saslis-Lagoudakis, CI Wright, CMFB Roersch, CO Webb, CO Webb, CO Webb, CW Lukhoba, D Karou, DD Soejarto, DE Fairbrothers, DE Moerman, DE Moerman, DE Moerman, DS Fabricant, E Douwes, E Pacharawongsakda, EG Baker, Elizabeth M. Williamson, F Forest, FA Bisby, FA Mendonça, FEM Cook, Félix Forest, G Bentham, GP Lewis, GT Prance, H Harms, I Sanmartin, J Felsenstein, J Harborne, J Shaw, J Tao, JB Harborne, JD Thompson, JD Weete, JJ Doyle, JK Grover, JLS Taylor, JM Lock, John W. Stiller, JP Rojo, Julie A. Hawkins, KA Crandall, KW Hilu, L Csiba, Louise Francis, M Lavin, M Leonti, M Wink, M Wink, MD Crisp, MD Pirie, MF Fay, MF Wojciechowski, MGK Bay-Smidt, MJ Donoghue, MM Larsen, N Bletter, N Bletter, N Nagaraju, N Nagaraju, N Rønsted, N Zamora, NL Etkin, NR Farnsworth, P Taberlet, P Taubert, PM Hollingsworth, R Gibbs, R Lahaye, RAc Ribeiro, RD Firn, RM Polhill, RT Pennington, RT Trotter, RW Li, S Bertani, S Chen, S Newmaster, SA Kelchner, SP Dhanabal, SY Strauss, T Reynolds, UP de Albuquerque, V Muñoz, V Reyes-Garcia, V Savolainen, V Vats, Vincent Savolainen, VK Kondeti, VT Amiguet, W Arthur, WC McClatchey, WH Lewis, WJ Kress, Y Sun, Y Uprety, YLN Murthy, Ş Procheş   +125 more
core   +3 more sources

The Phylogeny of Rationality [PDF]

Cognitive Science, 1993
A rational agent has beliefs reflecting the state of its environment, and likes or dislikes Its situation. When it finds the world not entirely to Its liking, it tries to change that. We can, accordingly, evaluate a system of cognition in terms of its probable success in bringing about situations that are to the agent's liking.
openaire   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Food Webs: Experts Consuming Families of Experts

, 2005
The question what determines the structure of natural food webs has been listed among the nine most important unanswered questions in ecology. It arises naturally from many problems related to ecosystem stability and resilience.
Amemiya, T., Itoh, K., Matsuda, H., Rossberg, A. G.   +3 more
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Inferring Transcript Phylogenies [PDF]

2011 IEEE International Conference on Bioinformatics and Biomedicine, 2011
Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals–some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite much research on exon and intron evolution, little is known about the evolution of transcripts.
Christinat, Yann, Moret, Bernard
openaire   +6 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

The Complexity of Rooted Phylogeny Problems

, 2010
Several computational problems in phylogenetic reconstruction can be formulated as restrictions of the following general problem: given a formula in conjunctive normal form where the literals are rooted triples, is there a rooted binary tree that ...
Bodirsky, Manuel, Mueller, Jens K
core   +2 more sources