Results 41 to 50 of about 5,999,000 (295)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Association of body mass index with peer aggression, reaction to peer aggression and physical activity in rural Chinese children

Frontiers in Public Health
ObjectivesTo investigate the relationship between body mass index (BMI) and peer aggression, reaction to peer aggression, and physical activity in rural Chinese children.Materials and methodsThe Chinese version of the Peer Aggression and Reactive ...
Sixiang Tao, Sixiang Tao, Hongzhao Wang, Yaming Song, Denise Koh   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Roles of Anger, Conflict With Parents and Peers, and Social Reinforcement in the Early Development of Physical Aggression

, 2023
Click on the DOI link to access this book chapter (may not be free).This chapter examines the origins of physical aggression and violence from a developmental perspective.
Brooker, Monica S., Schrepferman, Lynn M., Stoolmiller, Mike, Snyder, James J.   +3 more
core   +1 more source

Position of aggressiveness in common latent space of PEN model and model Big Five Plus Two [PDF]

Psihologija, 2012
The purpose of this research was to examine the relations between different aspects of aggressiveness and personality traits. Buss-Perry Aggression Questionnaire (AQ), Eysenck Personality Questionnaire (EPQ), which represent psychobiological model ...
Dinić Bojana, Smederevac Snežana
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Aggression Type Influences Perceptions of a Woman’s Body Size, Personality, and Behavior

Evolutionary Psychology, 2020
Although women engage in both physical and nonphysical aggression, little is known about how aggression type influences perceptions of their morphology, personality, and social behavior.
Jaime L. Palmer-Hague
doaj   +1 more source

Parenting Practices and Aggression in Childhood Behaviour Disorders

Pakistan Armed Forces Medical Journal, 2023
Objective: To determine the association between parenting practices and aggression in children with behaviour disorders. Study Design: Cross-sectional study.
Fatima Rahman, Shazia Maqbool, Anam Ali, Talha Mahmud, Hina Azhar, Aisha Farid   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source