Results 31 to 40 of about 244,562 (235)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Avaliação da resistência da pele de tilápia do Nilo (Oreochrmis niloticus) nos sentidos longitudinal, transversal e diagonal, depois de submetida ao curtimento com sais de cromo e recurtimento com diferentes agentes curtentes = Evaluation of resistance of the Nile tilapia (Oreochromis niloticus) skin in longitudinal, transversal and diagonal position after tanning with chromium salts and retanning with different tanning substances

Acta Scientiarum: Animal Sciences, 2006
O objetivo do trabalho foi avaliar a resistência da pele da Tilápia do Nilo (Oreochromis niloticus) no sentido longitudinal, transversal e diagonal, depois de curtida com sais de cromo e recurtida por diferentes técnicas de recurtimento.
Maria Luiza Rodrigues de Souza, Maria del Carmen Aguilar Valdez, Amanda Lilian Vieira Hoch, Karla Fabrícia de Oliveira, Inácio Rigolon Matos, Antonio Manoel Camin   +5 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Physico - Mechanical Properties Of Improved Soil By Pvd Incorporating Surcharge And Vacuum Preloading: A Case Study In Long Phu, Soc Trang, Vietnam

Journal of Applied Science and Engineering
The soft soil of Long Phu thermal power plant in Soc Trang province of southern Vietnam was treated by the PVD incorporating surcharge and vacuum preloading method. To evaluate the effectiveness of this method, experimental in-situ research combined with
Nguyen Thi Nu, Do Minh Ngoc, Vu Dinh Tho
doaj   +1 more source

A Multi-Component Conical Spring Model of Soft Tissue in Virtual Surgery

IEEE Access, 2020
With the rapid development of optical system and medical robotic technology, the virtual surgery approach has achieved good progress but also faces many challenges.
Bin Dong, Jianqun Li, Guojie Yang, Xiaochun Cheng, Qinguo Gang   +4 more
doaj   +1 more source

Influence of silicon-dioxide nanoparticles in cementitious mortars: verification using x-ray diffraction, thermal analysis, physical, and mechanical tests

Materials Research Express, 2023
In recent years, nanotechnology has been applied to building materials, such as cementitious composites (e.g., mortar and concrete), to improve their properties.
F K G Andrade, T A C Pires, J J R Silva
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Study on hydrogeological characteristics of an alkali residue site in Tianjin port

Yantu gongcheng xuebao
In order to understand the physical, mechanical and engineering properties of alkali residue: a special soil mass, and summarize its hydrogeological characteristics, a large number of indoor physical tests: direct shear tests and permeability tests are ...
YE Jingxiong 1, SUN Huaijun 1, PAN Zidong 2
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source