Results 131 to 140 of about 8,035,377 (307)

MacFadden's Physical Training [PDF]

, 1899
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MacFadden, Bernarr
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Synthesis and characterization of nanocrystalline Mn-Zn ferrites obtained via hydrothermal method using Aloe barbadensis Mill (Asphodelaceae) extract for the treatment of water contaminated with Congo red

South African Journal of Chemical Engineering
Nanocrystalline ferrites of the Mn1-xZnxFe2O4 system (x = 0, 0.2, 0.4, 0.6, 0.8, and 1.0) were synthesized with varying Mn and Zn contents using a hydrothermal method assisted with Aloe barbadensis Mill (Aloe vera) extract as adsorbent materials in the ...
Melissa Quevedo Lopez, Fernanda Pilaquinga, Alexis Debut, Alberto Albis Arrieta, Andrés Rosales Rivera, Zulia Caamaño De Avila   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Aharonov-Bohm effect for excitons in a semiconductor quantum ring dressed by circularly polarized light

, 2015
We show theoretically that the strong coupling of circularly polarized photons to an exciton in ringlike semiconductor nanostructures results in physical nonequivalence of clockwise and counterclockwise exciton rotations in the ring.
Shelykh, Ivan A., Sigurdsson, Helgi, Kibis, Oleg Vasilyevich   +2 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Optically controlled periodical chain of quantum rings

, 2016
We demonstrated theoretically that a circularly polarized electromagnetic field substantially modifies electronic properties of a periodical chain of quantum rings.
Hasan, M., Iorsh, I. V., Shelykh, Ivan A., Kibis, O. V.   +3 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evaluating Variability in Extracellular Vesicle Characterization Across Measurement Techniques

Journal of Extracellular Biology
Reliable, reproducible, and standardized characterization of extracellular vesicles (EVs) remains a central challenge due to methodological variability across analytical platforms and intrinsic EV heterogeneity within and across biofluids.
Premanshu K. Singh, Ali F. Usmani, Debmalya Halder, Jenna Miller, Tharune Kanagasabai, Patricia Sarchet, Kevin Weller, George J. Klarmann, Raphael E. Pollock, Federica Calore, Shaurya Prakash   +10 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source