Results 91 to 100 of about 156,415 (241)

Soft Robotic Excretory Care Simulator for Nursing Education: Functional and Perceptual Biomimetics Approach

open access: yesAdvanced Robotics Research, EarlyView.
A soft robotic simulator is developed to replicate the digital removal of feces (DRF), a sensitive yet essential nursing procedure. Integrating soft actuators, sensors, and a realistic rectal model, the simulator balances functional fidelity with perceptual realism. Engineering evaluations and nurse feedback confirm its potential to enhance training in
Shoko Miyagawa   +10 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

Motor competence, physical activity, and perceived motor competence: A relational systems approach

open access: yes, 2022
Motor competence, physical activity, and perceived motor competence: A relational systems ...
ABD Santos (14647643)   +3 more
core   +1 more source

Relationships between actual competence, perceived physical competence, social support, enjoyment and objectively measured physical activity among children and adolescents

open access: yes, 2012
According to Competence Motivation Theory (Harter, 1978; Weiss 2000), children are more likely to participate in behaviours such as physical activity if their experiences are enjoyable, with enjoyment coming from several sources.
Angelee-Jane Boyd (20163027)
core  

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

open access: yesAdvanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du   +4 more
wiley   +1 more source

PROFESSIONAL COMPETENCE DEVELOPMENT FOR ADAPTED PHYSICAL EDUCATION

open access: yesПедагогически форум, 2019
The children with special educational needs are educated in a friendly environment in kindergarden and in primary school icluding during gym classes. The aim of this study is to analyze the level of development of prfessional competency of future kindergarten and primary school teachers for adapted education during gym classes.
openaire   +2 more sources

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

open access: yesAdvanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer   +17 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang   +16 more
wiley   +1 more source

Relationship between Motor Skill Competence and Physical Activity in Girls

open access: yes, 2015
This study examined the relationship between motor skill competence, and physical activity in 8–9 years-old girls (N=352). Locomotor and object control skill competence was assessed, using the Test of Gross Motor Development-2, and the Physical Activity ...
Fatemah Khodaverdi, Abbas Bahram
core  

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